GPRC5a suppresses the proliferation of non-small cell lung cancer under wild type p53 background

Introduction: GPRC5a plays an important role in many types of cancers with intriguing dual functions. GPRC5a acts as oncogene or tumor suppressor in different types of cancer. It is interesting to illustrate why GPRC5a functions differently. Methods: Data mining method were used to analyze the potential prognostic value of GPRC5a expression for Non-Small Cell Lung Cancer (NSCLC) lung cancer patients. Then we used cell models to further investigate the effect of p53 mutation on GPRC5a expression and the thereafter cell biological behaviors. Results: Our results present here showed High mRNA-level expression of GPRC5a was associated with worse overall survival about lung cancer patients; mutation of p53 gene could result in up regulation of GPRC5a expression and promotion of cell proliferation in lung cancer cells. Our results not only demonstrate the role of GPRC5a as a tumor suppressor in lung cancer, but also revealed the tumor suppressive factor p53 regulated tightly on GPRC5a and cell growth of NSCLC cancer. Conclusions: Our results demonstrated that p53 upregulated GPRC5a expression in NSCLC cells, and the loss of p53 expression in NSCLC may be one of the mechanisms leading to the decreased GPRC5a expression in NSCLC.