Altered physiology of mesenchymal stem cells in the pathogenesis of adolescent idiopathic scoliosis

被引：4

作者：

Ko, Dai Sik ^{[1
]}

Kim, Yun Hak ^{[2
,3
]}

Goh, Tae Sik ^{[4
,5
]}

Lee, Jung Sub ^{[4
,5
]}

机构：

[1] Gachon Univ, Gil Med Ctr, Div Vasc Surg, Dept Surg, Incheoz 21565, South Korea

[2] Pusan Natl Univ, Dept Anat, Sch Med, Yangsan 50612, South Korea

[3] Pusan Natl Univ, Dept Biomed Informat, Sch Med, Yangsan 50612, South Korea

[4] Pusan Natl Univ Hosp, Dept Orthopaed Surg, Busan 49241, South Korea

[5] Pusan Natl Univ Hosp, Biomed Res Inst, Busan 49241, South Korea

来源：

WORLD JOURNAL OF CLINICAL CASES | 2020年 / 8卷 / 11期

基金：

新加坡国家研究基金会;

关键词：

Adolescent idiopathic scoliosis; Mesenchymal stem cell; Bioinformatics; Transcriptome; Proteome; BONE-MINERAL DENSITY; DIFFERENTIATION; RECEPTOR; POLYMORPHISM; EXPRESSION; OSTEOPENIA; ETIOLOGY; RNA;

D O I：

10.12998/wjcc.v8.i11.2102

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adolescent idiopathic scoliosis is the most common spinal deformity during puberty, especially in females. It is characterized by aberrant skeletal growth and generalized reduced bone density, which is associated with impaired bone mineral metabolism. Despite recent progress in multidisciplinary research to support various hypotheses, the pathogenesis of Adolescent idiopathic scoliosis is still not clearly understood. One of the hypothesis is to study the role of mesenchymal stem cells due to its involvement in the above-mentioned bone metabolic abnormalities. In this review, we will summarize reported literatures on the role of mesenchymal stem cells, particularly in the pathogenesis of Adolescent idiopathic scoliosis. In addition, we will describe the research on mesenchymal stem cells of Adolescent idiopathic scoliosis performed using bioinformatics tools.

引用

页码：2102 / 2110

页数：10

共 51 条

[31] Human trabecular bone cells are able to express both osteoblastic and adipocytic phenotype: Implications for osteopenic disorders [J].