Cardinal roles of miRNA in cardiac development and disease

被引：23

作者：

Feng YuLiang ^{[1
,2
]}

Yu XiYong ^{[1
]}

机构：

[1] Guangdong Acad Med Sci, Guangdong Gen Hosp, Med Res Ctr, Guangzhou 510080, Guangdong, Peoples R China

[2] So Med Univ, Pharmaceut Sch, Guangzhou 510515, Guangdong, Peoples R China

来源：

SCIENCE CHINA-LIFE SCIENCES | 2011年 / 54卷 / 12期

基金：

中国国家自然科学基金;

关键词：

miRNA; cardiac; development; disease; MUSCLE-SPECIFIC MICRORNA; DOWN-REGULATION; HUMAN HEART; SIRTUIN; EXPRESSION; HYPERTROPHY; MECHANISM; REPOLARIZATION; CONTRIBUTES; CALCINEURIN;

D O I：

10.1007/s11427-011-4257-8

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

MicroRNAs (miRNAs) are small noncoding RNAs that are emerging as pivotal modulators in virtually all aspects of cardiac biology, from cardiac development to cardiomyocyte survival and hypertrophy. The miRNA profiling, following gain- and loss-of-function studies using in vitro and in vivo models, has identified wide-ranging functions for miRNAs in the heart, providing new perspectives on their contributions to cardiac pathogenesis, and revealing potential therapeutic targets and diagnostic biomarkers. This review summarizes current progress in regulation of miRNAs in heart development and disease.

引用

页码：1113 / 1120

页数：8

共 69 条

[1] Thioredoxin1 as a negative regulator of cardiac hypertrophy [J].

Ago, Tetsuro ;

Sadoshima, Junichi .

ANTIOXIDANTS & REDOX SIGNALING, 2007, 9 (06) :679-687

[2] Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction [J].

Ai, Jing ;

Zhang, Rong ;

Li, Yue ;

Pu, Jielin ;

Lu, Yanjie ;

Jiao, Jundong ;

Li, Kang ;

Yu, Bo ;

Li, Zhuqin ;

Wang, Rongrong ;

Wang, Lihong ;

Li, Qiang ;

Wang, Nina ;

Shan, Hongli ;

Li, Zhongyu ;

Yang, Baofeng .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 391 (01) :73-77

[3] Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation [J].

Bagga, S ;

Bracht, J ;

Hunter, S ;

Massirer, K ;

Holtz, J ;

Eachus, R ;

Pasquinelli, AE .

CELL, 2005, 122 (04) :553-563

[4] Biogenesis and Regulation of Cardiovascular MicroRNAs [J].

Bauersachs, Johann ;

Thum, Thomas .

CIRCULATION RESEARCH, 2011, 109 (03) :334-347

[5] MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice [J].

Callis, Thomas E. ;

Pandya, Kumar ;

Seok, Hee Young ;

Tang, Ru-Hang ;

Tatsuguchi, Mariko ;

Huang, Zhan-Peng ;

Chen, Jian-Fu ;

Deng, Zhongliang ;

Gunn, Bronwyn ;

Shumate, Janelle ;

Willis, Monte S. ;

Selzman, Craig H. ;

Wang, Da-Zhi .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (09) :2772-2786

[6] Exosomes/microvesicles as a mechanism of cell-to-cell communication [J].

Camussi, Giovanni ;

Deregibus, Maria C. ;

Bruno, Stefania ;

Cantaluppi, Vincenzo ;

Biancone, Luigi .

KIDNEY INTERNATIONAL, 2010, 78 (09) :838-848

[7] MicroRNA-133 controls cardiac hypertrophy [J].

Care, Alessandra ;

Catalucci, Daniele ;

Felicetti, Federica ;

Bonci, Desiree ;

Addario, Antonio ;

Gallo, Paolo ;

Bang, Marie-Louise ;

Segnalini, Patrizia ;

Gu, Yusu ;

Dalton, Nancy D. ;

Elia, Leonardo ;

Latronico, Michael V. G. ;

Hoydal, Morten ;

Autore, Camillo ;

Russo, Matteo A. ;

Dorn, Gerald W., II ;

Ellingsen, Oyvind ;

Ruiz-Lozano, Pilar ;

Peterson, Kirk L. ;

Croce, Carlo M. ;

Peschle, Cesare ;

Condorelli, Gianluigi .

NATURE MEDICINE, 2007, 13 (05) :613-618

[8] Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure [J].

Chen, Jian-Fu ;

Murchison, Elizabeth P. ;

Tang, Ruhang ;

Callis, Thomas E. ;

Tatsuguchi, Mariko ;

Deng, Zhongliang ;

Rojas, Mauricio ;

Hammond, Scott M. ;

Schneider, Michael D. ;

Selzman, Craig H. ;

Meissner, Gerhard ;

Patterson, Cam ;

Hannon, Gregory J. ;

Wang, Da-Zhi .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (06) :2111-2116

[9] TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing [J].

Chendrimada, TP ;

Gregory, RI ;

Kumaraswamy, E ;

Norman, J ;

Cooch, N ;

Nishikura, K ;

Shiekhattar, R .

NATURE, 2005, 436 (7051) :740-744

[10] MicroRNAs are aberrantly expressed in hypertrophic heart - Do they play a role in cardiac hypertrophy? [J].

Cheng, Yunhui ;

Ji, Ruirui ;

Yue, Junming ;

Yang, Jian ;

Liu, Xiaojun ;

Chen, He ;

Dean, David B. ;

Zhang, Chunxiang .

AMERICAN JOURNAL OF PATHOLOGY, 2007, 170 (06) :1831-1840

← 1 2 3 4 5 6 7 →