The use of medication adherence guidelines in medication taking behaviour research

被引:7
作者
Bekker, Charlotte L. [1 ]
Aslani, Parisa [2 ]
Chen, Timothy F. [2 ]
机构
[1] Radboud Univ Nijmegen, Res Inst Hlth Sci, Dept Pharm, Med Ctr, Geer Grootepl Zuid 10, NL-6511 GA Nijmegen, Netherlands
[2] Univ Sydney, Sch Pharm, Fac Med & Hlth, Sydney, NSW, Australia
关键词
Medication adherence; Reporting guidelines; Research standards; Assessment instruments; PERSISTENCE; OUTCOMES; DISCONTINUATION; INTERVENTIONS; NONADHERENCE; TERMINOLOGY; ASSOCIATION; CHECKLIST; VALIDITY; THERAPY;
D O I
10.1016/j.sapharm.2021.08.006
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Medication nonadherence continues to be a serious issue in a range of long-term medical conditions and has been studied extensively over the past few decades. However, despite the plethora of research studies on medication adherence, poor methodological rigour in many studies has contributed to limited generalisability of the positive findings, limited impact on patients' medication adherence, and inability to compare between studies. This paper focuses on current guidelines designed specifically for research on medication adherence. It discusses key elements to consider during study design, selection of adherence measurements, and reporting on medication adherence research, to ensure a higher quality of research in medication adherence. Overall, there appears to be variations in adherence terminology reported in the literature despite improvements in defining medication taking behaviour and the availability of taxonomies. In addition, limited guidance exists on how best to measure adherence. Recommendations are provided on appropriate adherence measures for the adherence behaviour being investigated, including careful consideration of adherence concepts, validity of adherence instruments, appropriate instrument selection, definition of nonadherence threshold, and how to report medication adherence. Improving adherence research requires greater clarity and standardisation of descriptions of nonadherence behaviour, increased methodological rigour in study designs, better selection of adherence measurements, and comprehensive reporting.
引用
收藏
页码:2325 / 2330
页数:6
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