Role of transcription factor NFAT in the immune response

被引：15

作者：

Kuklina, EM ^{[1
]}

Shirshev, SV ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Ecol & Genet Microorgan, Perm 614081, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2001年 / 66卷 / 05期

关键词：

NFAT; immune response; apoptosis; lymphocytes; macrophages; mast cells; cytokines;

D O I：

10.1023/A:1010238931555

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Molecular mechanisms of activation of nuclear factor NFAT in cef is of the lympho-myeloid complex are considered. Members of the NFAT family regulate transcription of genes encoding proteins involved in the induction and/or regulation of the immune response. It is possible that altered transcription activity of NFAT under conditions of its deficit or blockade of expression may account for changes in the immune status of an organism.

引用

页码：467 / 475

页数：9

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