Peroxiredoxin 6 secreted by Schwann-like cells protects neuron against ischemic stroke in rats via PTEN/PI3K/AKT pathway

被引：12

作者：

Tang, Bin ^{[1
,2
]}

Ni, Wei ^{[1
]}

Zhou, Jiqin ^{[1
]}

Ling, Yating ^{[1
]}

Niu, Dongdong ^{[1
]}

Lu, Xiaorui ^{[1
]}

Chen, Tianyan ^{[1
]}

Ramalingam, Murugan ^{[3
]}

Hu, Jiabo ^{[1
]}

机构：

[1] Jiangsu Univ, Sch Med, Jiangsu Key Lab Med Sci & Lab Med, Zhenjiang 212013, Jiangsu, Peoples R China

[2] Jinhu Cty Peoples Hosp, Dept Clin Lab, Huaian 211600, Jiangsu, Peoples R China

[3] Vellore Inst Technol, Sch Mech Engn, Biomat & Organ Engn Grp, Ctr Biomat, Vellore 632014, Tamil Nadu, India

来源：

TISSUE & CELL | 2021年 / 73卷

关键词：

Schwann-like cell; Peroxiredoxin; 6; Ischemic stroke; PTEN; PI3K; AKT; OXIDATIVE STRESS; INJURY; DAMAGE; OVEREXPRESSION; EXPRESSION; DEATH; ROS;

D O I：

10.1016/j.tice.2021.101635

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Schwann cells can promote the survival of damaged neurons and axon regeneration by secreting or releasing some proteins and factors which may provide effective strategies to the remedy for ischemic stroke. The models of middle cerebral artery occlusion and oxygen-glucose deprivation (OGD) were established. Peroxiredoxin 6 (PRDX6) was found in Schwann-like cell conditioned medium (SCLC-CM) by mass spectrometry. The rehabilitative performance of SCLC-CM on focal cerebral ischemia of rats and on OGD-induced PC12 cells were assessed. SCLC-CM significantly improved neurological recovery, reducing the infarct volume of rats after stroke. PRDX6 could significantly inhibit neuron apoptosis in the OGD injury by mediating oxidative stress and activating the PTEN/PI3K/AKT pathway. In conclusion, PRDX6 secreted by Schwann-like cell protects neuron against focal cerebral ischemia, SCLC-CM might be a new effective early intervention for ischemic stroke.

引用

页数：11

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