Polyphenols: Key Issues Involved in Chemoprevention of Prostate Cancer

被引：79
作者：
Cimino, Sebastiano [1 ]
Sortino, Giuseppe [1 ]
Favilla, Vincenzo [1 ]
Castelli, Tommaso [1 ]
Madonia, Massimo [2 ]
Sansalone, Salvatore [3 ]
Russo, Giorgio Ivan [1 ]
Morgia, Giuseppe [1 ]
机构：
[1] Univ Catania, Dept Urol, I-95125 Catania, Italy
[2] Univ Sassari, Dept Urol, I-07100 Sassari, Italy
[3] Univ Roma Tor Vergata, Dept Urol, Sch Med & Surg, Rome, Italy
来源：
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2012年 / 2012卷
关键词：
GREEN TEA POLYPHENOLS; I CLINICAL-TRIAL; MOLECULAR TARGETS; INDUCED APOPTOSIS; DIETARY AGENTS; SOY ISOFLAVONE; CURCUMIN; CELLS; GENISTEIN; RESVERATROL;
D O I：
10.1155/2012/632959
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Prostate cancer is is the most common solid neoplasm and it is now recognized as one of the most important medical problems facing the male population. Due to its long latency and its identifiable preneoplastic lesions, prostate cancer is an ideal target tumor for chemoprevention. Different compounds are available and certainly polyphenols represent those with efficacy against prostate cancer. This review take a look at activity and properties of major polyphenolic substances, such as epigallocatechin-3-gallate, curcumin, resveratrol and the flavonoids quercetin and genistein. Although the current studies are limited, mechanisms of action of polyphenols added with the lack of side effects show a a start for future strategies in prostate chemoprevention.
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页数：8
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