Applications of the Nicholas Reaction in the Synthesis of Natural Products

被引：39
作者：
Kann, Nina [1 ]
机构：
[1] Chalmers, Dept Chem & Biol Engn, SE-41296 Gothenburg, Sweden
来源：
CURRENT ORGANIC CHEMISTRY | 2012年 / 16卷 / 03期
基金：
瑞典研究理事会;
关键词：
Alkaloid; cobalt alkyne complex; marine polyether; natural product synthesis; Nicholas reaction; terpene; ACETYLENE COBALT COMPLEX; 8-MEMBERED CYCLIC ETHERS; JKLM-RING FRAGMENT; STEREOSELECTIVE-SYNTHESIS; PROPARGYLIC SUBSTITUTION; CONVERGENT SYNTHESIS; ORGANIC-SYNTHESIS; FORMAL SYNTHESIS; CIGUATOXIN; 1B; ENANTIOSELECTIVE SYNTHESES;
D O I：
10.2174/138527212799499949
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The Nicholas reaction involves the treatment of a cobalt carbonyl-stabilized propargylic cation with a variety of nucleophiles to form a new carbon-carbon or carbon-heteroatom bond. Several features of this reaction make it especially well suited for applications in natural product synthesis, in particular when cyclic and polycyclic target molecules are involved. This review summarizes the results in this area from the last ten years, including approaches towards terpenes, alkaloids and marine natural products.
引用
收藏
页码：322 / 334
页数：13
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