Synthesis, antibacterial and antifungal evaluation of thio- or piperazinyl-substituted 1,4-naphthoquinone derivatives

被引：16

作者：

Ibis, Cemil ^{[1
]}

Ozsoy-Gunes, Zeliha ^{[2
]}

Tuyun, Amac Fatih ^{[3
]}

Ayla, Sibel Sahinler ^{[1
]}

Bahar, Hakan ^{[1
]}

Stasevych, Maryna V. ^{[4
]}

Musyanovych, Rostyslav Ya ^{[4
]}

Komarovska-Porokhnyavets, Olena ^{[3
]}

Novikov, Volodymyr ^{[4
]}

机构：

[1] Istanbul Univ, Fac Engn, Dept Chem, Istanbul, Turkey

[2] Istanbul Univ, Hasan Ali Yucel Educ Fac, Div Sci Educ, Dept Elementary Educ, Istanbul, Turkey

[3] Istanbul Univ, Fac Engn, Dept Engn Sci, Istanbul, Turkey

[4] Natl Univ Lviv Polytech, Dept Technol Biol Act Subst Pharm & Biotechnol, Lvov, Ukraine

来源：

JOURNAL OF SULFUR CHEMISTRY | 2016年 / 37卷 / 05期

关键词：

Piperazine; thiol; bipiperidine; 1; 4-naphthoquinone; antibacterial; antifungal activity; AGENTS; SAR;

D O I：

10.1080/17415993.2016.1187734

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of S-, S,S-, S,O-, N- and N,S-derivatives from 2,3-dichloro-1,4-naphthoquinone compound 1 were synthesized in different reaction media and evaluated for their antibacterial and antifungal activities. The structures of the novel products were characterized by spectroscopic methods, such as microanalysis, H-1 NMR, C-13 NMR and MS. Among the tested compounds 9, 12 and 18 are the most effective compounds against Candida tenuis as potent antifungal compounds. Compound 9 is also the most effective compound against Staphylococcus aureus as a potent antifungal compound.

引用

收藏

页码：477 / 487

页数：11

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