Phenolic Enriched Extract of Baccharis trimera Presents Anti-inflammatory and Antioxidant Activities

被引：38

作者：

de Oliveira, Cristiane B. ^{[1
,2
]}

Comunello, Lucimara N. ^{[1
]}

Lunardelli, Adroaldo ^{[2
]}

Amaral, Robson H. ^{[2
]}

Pires, Melissa G. S. ^{[2
]}

da Silva, Gabriela Lucas ^{[2
]}

Manfredini, Vanusa ^{[1
,3
]}

Vargas, Carmen Regla ^{[1
,3
]}

Gnoatto, Simone C. B. ^{[1
]}

de Oliveira, Jarbas R. ^{[2
]}

Gosmann, Grace ^{[1
]}

机构：

[1] Univ Fed Rio Grande do Sul, Fac Farm, BR-90610000 Porto Alegre, RS, Brazil

[2] Pontificia Univ Catolica Rio Grande do Sul PUCRS, Lab Biofis Celular & Inflamacao, BR-90619900 Porto Alegre, RS, Brazil

[3] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Serv Genet Med, BR-93050150 Porto Alegre, RS, Brazil

来源：

MOLECULES | 2012年 / 17卷 / 01期

关键词：

anti-inflammatory; antioxidant; Baccharis trimera; phenolic compounds; pleurisy; saponin; TAR; IDENTIFICATION;

D O I：

10.3390/molecules17011113

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Baccharis trimera is a plant popularly used as a tea and to treat gastrointestinal diseases and inflammatory processes as well. The total phenolic content was determined and the antioxidant and anti-inflammatory activities of six extracts (dichloromethane, ethyl acetate, butanol, aqueous, saponin and phenolic) from B. trimera were evaluated. Using carrageenan-induced pleurisy as a model of acute inflammation, the phenolic extract at 15 mg/kg decreased significantly the analyzed parameters when compared to the carrageenan group (p < 0.05), thus showing potential anti-inflammatory activity. The total phenolic content and antioxidant activity were evaluated by the Folin-Ciocalteau and DPPH methods, respectively. Phenolic and ethyl acetate extracts presented higher antioxidant activity (p < 0.05) than ascorbic acid. The phenolic extract also showed the highest antioxidant potential in relation to the other extracts, thus suggesting that the antioxidant and anti-inflammatory activities were due to the presence of phenolic compounds.

引用

页码：1113 / 1123

页数：11

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