Vaccines elicit highly conserved cellular immunity to SARS-CoV-2 Omicron

被引：353

作者：

Liu, Jinyan ^{[1
]}

Chandrashekar, Abishek ^{[1
]}

Sellers, Daniel ^{[1
]}

Barrett, Julia ^{[1
]}

Jacob-Dolan, Catherine ^{[1
,2
]}

Lifton, Michelle ^{[1
]}

McMahan, Katherine ^{[1
]}

Sciacca, Michaela ^{[1
]}

VanWyk, Haley ^{[1
]}

Wu, Cindy ^{[1
]}

Yu, Jingyou ^{[1
]}

Collier, Ai-ris Y. ^{[1
]}

Barouch, Dan H. ^{[1
,2
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[2] Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA

来源：

NATURE | 2022年 / 603卷 / 7901期

关键词：

D O I：

10.1038/s41586-022-04465-y

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The highly mutated SARS-CoV-2 Omicron (B.1.1.529) variant has been shown to evade a substantial fraction of neutralizing antibody responses elicited by current vaccines that encode the WA1/2020 spike protein(1). Cellular immune responses, particularly CD8(+)T cell responses, probably contribute to protection against severe SARS-CoV-2 infection(2-6). Here we showthat cellular immunity induced by current vaccines against SARS-CoV-2 is highly conserved to the SARS-CoV-2 Omicron spike protein. Individuals who received the Ad26.COV2.S or BNT162b2 vaccines demonstrated durable spike-specific CD8(+) and CD4(+)T cell responses, which showed extensive cross-reactivity against both the Delta and the Omicron variants, including in central and effector memory cellular subpopulations. Median Omicron spike-specific CD8(+)T cell responses were 82-84% of the WA1/2020 spike-specific CD8(+)T cell responses. These data provide immunological context for the observation that current vaccines still show robust protection against severe disease with the SARS-CoV-2 Omicron variant despite the substantially reduced neutralizing antibody responses(7,8).

引用

页码：493 / +

页数：16

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