Relationship between interpregnancy interval and birth defects in Washington State

被引:49
作者
Kwon, S. [1 ]
Lazo-Escalante, M. [2 ]
Villaran, M. V. [3 ]
Li, C. I. [4 ,5 ]
机构
[1] Univ Washington, Dept Surg, Seattle, WA 98195 USA
[2] Univ Peruana Cayetano Heredia, Epidemiol STD & HIV Unit, Sch Publ Hlth & Adm, Lima, Peru
[3] US Naval Med Res Ctr Detachment NMRCD, Dept Virol, Lima, Peru
[4] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA
[5] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA
关键词
birth defects; interpregnancy interval; perinatal outcomes; CONGENITAL-MALFORMATIONS; INFANT-MORTALITY; MATERNAL AGE; RISK-FACTORS; PREGNANCY; FOLATE; OUTCOMES; HOMOCYSTEINE;
D O I
10.1038/jp.2011.49
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: Interpregnancy interval (IPI) influences numerous adverse perinatal outcomes. IPI's impact on birth defects is unclear. Study Design: We conducted a population-based case-control study, using 1998 to 2008 administrative data from Washington State. A total of 10 772 cases, women whose second of two births resulted in an infant with a birth defect, were compared with 32 310 controls, women whose second of two births did not result in an infant with a birth defect. Result: Compared with mothers with an IPI between 18 to 23 months, those with an IPI <6 months or >= 60 months had elevated risks of delivering an infant with a birth defect (odds ratio = 1.15, 95% confidence interval: 1.03 to 1.28, and odds ratio 1.15, 95% confidence interval: 1.04 to 1.26, respectively). Conclusion: We observed a J-shaped relationship between IPI and risk of having an infant with a birth defect. As this is one of the first studies to evaluate this association, confirmatory studies are needed. Journal of Perinatology (2012) 32, 45-50; doi:10.1038/jp.2011.49; published online 5 May 2011
引用
收藏
页码:45 / 50
页数:6
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