FET(EWSR1)-TFCP2 Rhabdomyosarcoma: An Additional Example of this Aggressive Variant with Predilection for the Gnathic Bones

被引：29
作者：
Koutlas, Ioannis G. [1 ]
Olson, Damon R. [2 ]
Rawwas, Jawhar [3 ]
机构：
[1] Univ Minnesota, Sch Dent, Div Oral & Maxillofacial Pathol, 515 Delaware St SE 16 116B, Minneapolis, MN 55455 USA
[2] Childrens Minnesota, Dept Lab Med & Pathol, Minneapolis, MN USA
[3] Childrens Minnesota, Pediat Hematol & Oncol, Minneapolis, MN USA
来源：
HEAD & NECK PATHOLOGY | 2021年 / 15卷 / 01期
关键词：
Rhabdomyosarcoma; Mandible; EWSR1-TFCP2; FUSION; EXPRESSION; EWSR1;
D O I：
10.1007/s12105-020-01189-1
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
An example of a mandibular rhabdomyosarcoma in a 15-year-old male is described featuring EWSR1-TFCP2 fusion with homolateral lymph node metastasis and apparent metastasis to the thoracic vertebra T7. This type of rhabdomyosarcoma has preference for the craniofacial skeleton. Histologically, the tumor was composed of spindle and epithelioid cells characterized by nuclear pleomorphism, cytologic atypia and brisk mitotic activity. Immunohistochemically, it featured diffuse positive nuclear staining MYOD1, only focal staining for myogenin and patchy cytoplasmic staining for desmin. Tumor cells were positive for keratins and nuclear staining for SATB2 was also observed. Interestingly, tumor cells were diffusely positive for calponin. Currently, the patient is under chemotherapy treatment.
引用
收藏
页码：374 / 380
页数：7
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