Thyroid hormone controls multiple independent programs required for limb development in Xenopus laevis metamorphosis

被引：55
作者：
Brown, DD
Cai, LQ
Das, B
Marsh-Armstrong, N
Schreiber, AM
Juste, R
机构：
[1] Carnegie Inst Washington, Dept Embryol, Baltimore, MD 21218 USA
[2] Johns Hopkins Univ, Dept Neurosci, Sch Med, Baltimore, MD 21205 USA
[3] Kennedy Krieger Inst, Baltimore, MD 21205 USA
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2005年 / 102卷 / 35期
关键词：
transgenesis; cell autonomy; thyroid hormone receptor; DNA replication;
D O I：
10.1073/pnas.0505989102
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Thyroid hormone (TH) is required for limb development in Xenopus laevis. Specific cell types in the growing limb were targeted for expression of a dominant negative form of the TH receptor by sperm-mediated transgenesis. Limb muscle development, the innervation of muscle from the spinal cord, and cartilage growth can be inhibited without affecting patterning of the limb or differentiation of other cell types. Remodeling of the skin occurs late in metamorphosis after the limb has formed. The coordination of these independent programs is affected in part by the control that TH exerts over DNA replication in all cell types of the limb.
引用
收藏
页码：12455 / 12458
页数：4
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