Albumin-Bioinspired Gd:CuS Nanotheranostic Agent for In Vivo Photoacoustic/Magnetic Resonance Imaging-Guided Tumor-Targeted Photothermal Therapy

被引:376
作者
Yang, Weitao [1 ,2 ]
Guo, Weisheng [3 ]
Le, Wenjun [2 ]
Lv, Guoxian [1 ]
Zhang, Fuhe [2 ]
Shi, Lei [2 ]
Wang, Xiuli [2 ]
Wang, Jun [2 ]
Wang, Sheng [1 ]
Chang, Jin [1 ]
Zhang, Bingbo [2 ]
机构
[1] Tianjin Univ, Collaborat Innovat Ctr Chem Sci & Engn, Tianjin Engn Ctr Micronano Biomat & Detect Treatm, Sch Mat Sci & Engn,Sch Life Sci, Tianjin 300072, Peoples R China
[2] Tongji Univ, Sch Med, Inst Biomed Engn & Nano Sci, Inst Photomed,Shanghai Skin Dis Hosp, Shanghai 200443, Peoples R China
[3] Natl Ctr Nanoscience & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, 11 Beiyitiao, Beijing 100190, Peoples R China
基金
中国国家自然科学基金;
关键词
biomimetic mineralization; CuS; photothermal therapy; photoacoustic; MR imaging; COPPER SULFIDE NANOPARTICLES; SEMICONDUCTING POLYMER NANOPARTICLES; PROTEIN-DIRECTED SYNTHESIS; CORE-SHELL NANOPARTICLES; QUANTUM DOTS; IMMUNOLOGICAL RESPONSES; MAGNETIC-RESONANCE; THERANOSTIC AGENT; FACILE SYNTHESIS; CONTRAST AGENTS;
D O I
10.1021/acsnano.6b05760
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Photothermal therapy (PTT) is attracting increasing interest and becoming more widely used for skin cancer therapy in the clinic, as a result of its noninvasiveness and low systemic adverse effects. However, there is an urgent need to develop biocompatible PTT agents, which enable accurate imaging, monitoring, and diagnosis. Herein, a biocompatible Gd-integrated CuS nanotheranostic agent (Gd:CuS@BSA) was synthesized via a facile and environmentally friendly biomimetic strategy, using bovine serum albumin (BSA) as a biotemplate at physiological temperature. The as-prepared Gd:CuS@BSA nanoparticles (NPs) with ultrasmall sizes (ca. 9 nm) exhibited high photothermal conversion efficiency and good photo stability under near-infrared (NIR) laser irradiation. With doped Gd species and strong tunable MR absorbance, Gd:CuS@BSA NPs demonstrate prominent tumor-contrasted imaging performance both on the photoacoustic and magnetic resonance imaging modalities. The subsequent Gd:CuS@BSA-mediated PTT result shows high therapy efficacy as a result of their potent NIR absorption and high photothermal conversion efficiency. The immune response triggered by Gd:CuS@BSA-mediated PTT is preliminarily explored. In addition, toxicity studies in vitro and in vivo verify that Gd:CuS@BSA NPs qualify as biocompatible agents. A biodistribution study demonstrated that the NPs can undergo hepatic clearance from the body. This study highlights the practicality and versatility of albumin-mediated biomimetic mineralization of a nanotheranostic agent and also suggests that bioinspired Gd:CuS@BSA NPs possess promising imaging guidance and effective tumor ablation properties, with high spatial resolution and deep tissue penetration.
引用
收藏
页码:10245 / 10257
页数:13
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