Phenolic compounds isolated from Zingiber officinale roots inhibit cell adhesion

被引：24

作者：

Lee, Seung Woong ^{[1
]}

Lim, Ju-Hwan ^{[1
,2
]}

Kim, Min Seok ^{[1
]}

Jeong, Ji-Hak ^{[1
]}

Song, Gyu-Yong ^{[2
]}

Lee, Woo Song ^{[1
]}

Rho, Mun-Chual ^{[1
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol, Ecofriendly Biomat Res Ctr, Jeongeup Si 580185, Jeonbuk, South Korea

[2] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

来源：

FOOD CHEMISTRY | 2011年 / 128卷 / 03期

关键词：

Zingiber officinale; Zingiberaceae; Gingerols; Shogaols; Cell adhesion molecules; THP-1; cells; GINGER; ANTIBODY; MACROPHAGES; ANTAGONISTS; EXPRESSION; PRINCIPLES; PSORIASIS; MIGRATION; DISEASE; SYSTEM;

D O I：

10.1016/j.foodchem.2011.03.095

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Inhibitors of cell adhesion molecule-mediated cell adhesion might be novel therapeutic agents for the treatment of various inflammatory diseases. In this study, nine phenolic compounds were isolated from the methanol extracts of Zingiber officinale roots by bioactivity-guided fractionation. The structures of the compounds were determined by spectroscopic analysis (H-1, C-13 NMR and MS), to be 6-gingerol (1), 8-gingerol (2), 10-gingerol (3), 6-shogaol (4), 8-shogaol (5), 10-shogaol (6), dehydro-6-gingerdione (7), dehydro-10-gingerdione (8) and 6-paradol (9). Compounds 3, 4, 5 and 7 inhibited direct binding between slCAM-1 and LFA-1 of the THP-1 cells in a dose-dependent manner with IC50 values of 57.6, 27.1, 65.4 and 62.0 mu M, respectively. Compounds 4 and 7 had an inhibitory effect on direct binding between sVCAM-1 and VLA-4 of THP-1 cells. These results suggest that the phenolic compounds from Z. officinale roots are good candidates for therapeutic strategies aimed at inflammation. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：778 / 782

页数：5

共 30 条

[1]

Afzal M., 1992, DRUG METABOLISM DRUG, V18, P159

[2]

Awang DVC., 1992, Can Pharm J, V125, P309

[3] NEW SYNTHESIS OF PUNGENT PRINCIPLES OF GINGER - ZINGERONE, GINGEROL AND SHOGAOL [J].

BANNO, K ;

MUKAIYAMA, T .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1976, 49 (05) :1453-1454

[4] Lymphocyte migration in lymphocyte function-associated antigen (LFA)-1-deficient mice [J].

Berlin-Rufenach, C ;

Otto, F ;

Mathies, M ;

Westermann, J ;

Owen, MJ ;

Hamann, A ;

Hogg, N .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (09) :1467-1478

[5] Endothelial cells proactively form microvilli-like membrane projections upon intercellular adhesion molecule I engagement of leukocyte LFA-1 [J].

Carman, CV ;

Jun, CD ;

Salas, A ;

Springer, TA .

JOURNAL OF IMMUNOLOGY, 2003, 171 (11) :6135-6144

[6]

Cotran RS, 1998, PATHOL BIOL, V46, P164

[7] Novel bioassay system for evaluating anti-oxidative activities of food items: Use of basolateral media from differentiated Caco-2 cells [J].

Eguchi, A ;

Murakami, A ;

Ohigashi, H .

FREE RADICAL RESEARCH, 2005, 39 (12) :1367-1375

[8] Effects of administration of a single dose of a humanized monoclonal antibody to CD11a on the immunobiology and clinical activity of psoriasis [J].

Gottlieb, A ;

Krueger, JG ;

Bright, R ;

Ling, M ;

Lebwohl, M ;

Kang, S ;

Feldman, S ;

Spellman, M ;

Wittkowski, K ;

Ochs, HD ;

Jardieu, P ;

Bauer, R ;

White, M ;

Dedrick, R ;

Garovoy, M .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2000, 42 (03) :428-435

[9] Psoriasis as a model for T-cell-mediated disease - Immunobiologic and clinical effects of treatment with multiple doses of efalizumab, an anti-CD11a antibody [J].

Gottlieb, AB ;

Krueger, JG ;

Wittkowski, K ;

Dedrick, R ;

Walicke, PA ;

Garovoy, M .

ARCHIVES OF DERMATOLOGY, 2002, 138 (05) :591-600

[10] Leukocyte-endothelial interactions: Clinical trials of anti-adhesion therapy [J].

Harlan, JM ;

Winn, RK .

CRITICAL CARE MEDICINE, 2002, 30 (05) :S214-S219

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