Treatment outcomes of integrase inhibitors, boosted protease inhibitors and nonnucleoside reverse transcriptase inhibitors in antiretroviral-naive persons starting treatment

Objectives Although outcomes of antiretroviral therapy (ART) have been evaluated in randomized controlled trials, experiences from subpopulations defined by age, CD4 count or viral load (VL) in heterogeneous real-world settings are limited. Methods The study design was an international multicohort collaboration. Logistic regression was used to compare virological and immunological outcomes at 12 +/- 3 months after starting ART with an integrase strand transfer inhibitor (INSTI), contemporary nonnucleoside reverse transcriptase inhibitor (NNRTI) or boosted protease inhibitor (PI/b) with two nucleos(t)ides after 1 January 2012. The composite treatment outcome (cTO) defined success as VL 750 cells/mu L or a 33% increase where the baseline CD4 count was >= 500 cells/mu L. Poisson regression compared clinical failures (AIDS/death >= 14 days after starting ART). Interactions between ART class and age, CD4 count, and VL were determined for each endpoint. Results Of 5198 ART-naive persons in the International Cohort Consortium of Infectious Diseases (RESPOND), 45.4% started INSTIs, 26.0% PI/b and 28.7% NNRTIs; 880 (17.4%) were aged > 50 years, 2539 (49.4%) had CD4 counts < 350 cells/mu L and 1891 (36.8%) had VL > 100 000 copies/mL. Differences in virological and immunological success and clinical failure among ART classes were similar across age groups (<= 40, 40-50 and > 50 years), CD4 count categories (<= 350 vs. > 350 cells/mu L) and VL categories at ART initiation (<= 100 000 vs. > 100 000 copies/mL), with all investigated interactions being nonsignificant (P > 0.05). Conclusions Differences among ART classes in virological, immunological and clinical outcomes in ART-naive participants were consistent irrespective of age, immune suppression or VL at ART initiation. While confounding by indication cannot be excluded, this provides reassuring evidence that such subpopulations will equally benefit from contemporary ART.