Silica Gel-Mediated Organic Reactions under Organic Solvent-Free Conditions

被引：26
|
作者：
Onitsuka, Satoaki [1 ]
Jin, Yong Zhi [1 ]
Shaikh, Ajam C. [1 ]
Furuno, Hiroshi [1 ]
Inanaga, Junji [1 ]
机构：
[1] Kyushu Univ, IMCE, Higashi Ku, Fukuoka 8128581, Japan
来源：
MOLECULES | 2012年 / 17卷 / 10期
关键词：
aromatic nitration; green synthetic process; heterogeneous reaction; Morita-Baylis-Hillman reaction; one-pot Wittig-type olefination; solid reaction medium; BAYLIS-HILLMAN REACTION; RARE-EARTH COMPLEXES; WITTIG REACTIONS; AROMATIC-COMPOUNDS; NITRIC-ACID; HETEROGENEOUS CATALYSIS; PHENOLIC-COMPOUNDS; PHOSPHORUS YLIDES; RATE ACCELERATION; IONIC LIQUIDS;
D O I：
10.3390/molecules171011469
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Silica gel was found to be an excellent medium for some useful organic transformations under organic solvent-free conditions, such as (1) the Friedel-Crafts-type nitration of arenes using commercial aqueous 69% nitric acid alone at room temperature, (2) one-pot Wittig-type olefination of aldehydes with activated organic halides in the presence of tributyl-or triphenylphosphine and Hunig's base, and (3) the Morita-Baylis-Hillman reaction of aldehydes with methyl acrylate. After the reactions, the desired products were easily obtained in good to excellent yields through simple manipulation.
引用
收藏
页码：11469 / 11483
页数：15
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