Frontotemporal Dementia: What Can the Behavioral Variant Teach Us about Human Brain Organization?

被引：100

作者：

Seeley, William W. ^{[1
]}

Zhou, Juan ^{[1
]}

Kim, Eun-Joo ^{[2
,3
]}

机构：

[1] Univ Calif San Francisco, Memory & Aging Ctr, Dept Neurol, San Francisco, CA 94143 USA

[2] Pusan Natl Univ, Sch Med, Pusan Natl Univ Hosp, Dept Neurol, Pusan, South Korea

[3] Med Res Inst, Pusan, South Korea

来源：

NEUROSCIENTIST | 2012年 / 18卷 / 04期

关键词：

anterior cingulate; anterior insula; frontotemporal dementia; functional connectivity; von Economo neuron; WHITE-MATTER DAMAGE; VON ECONOMO NEURONS; ALZHEIMERS-DISEASE; DEFAULT-MODE; NEURAL MECHANISMS; RESTING BRAIN; NETWORKS; CONNECTIVITY; UNIQUE; CORTEX;

D O I：

10.1177/1073858411410354

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The behavioral variant of frontotemporal dementia (bvFTD) slowly undermines emotion, social behavior, personal conduct, and decision making. These deficits occur in concert with focal neurodegeneration that can be quantified with modern structural and functional imaging and neuropathological methods. As a result, studies of bvFTD have helped to clarify brain structures, networks, and neurons that prove critical for normal social-emotional functioning. In this article, the authors review the evolving bvFTD literature and propose a simple, testable network-based working model for understanding bvFTD.

引用

页码：373 / 385

页数：13

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