Coxfa4l3, a novel mitochondrial electron transport chain Complex 4 subunit protein, switches from Coxfa4 during spermatogenesis

被引：16

作者：

Endou, Masahiro ^{[1
]}

Yoshida, Kaito ^{[1
]}

Hirota, Makoto ^{[1
]}

Nakajima, Chika ^{[1
]}

Sakaguchi, Atsumi ^{[1
]}

Komatsubara, Naoto ^{[2
]}

Kurihara, Yasuyuki ^{[3
]}

机构：

[1] Yokohama Natl Univ, Grad Sch Engn Sci, Yokohama, Kanagawa 2408501, Japan

[2] Yokohama Natl Univ, Coll Engn Sci, Yokohama, Kanagawa 2408501, Japan

[3] Yokohama Natl Univ, Fac Engn Sci, Lab Mol Biol, Yokohama, Kanagawa 2408501, Japan

来源：

MITOCHONDRION | 2020年 / 52卷

关键词：

Spermatogenesis; Electron transport chain; Hypoxia; CYTOCHROME-C-OXIDASE; NDUFA4L2; PROTEIN; GENE-EXPRESSION; CELLS; CARCINOMA;

D O I：

10.1016/j.mito.2020.02.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We identified Coxfa4l3, previously called Cl 5orf48 or Nmesl, as a novel accessory protein of Complex IV of the mitochondrial electron transport chain (ETC). Amino acid sequence comparison, the intracellular localization and the protein expression data showed that the protein is the third isoform of Coxfa4 and the expression of Coxfa4 and Coxfa4l3 proteins during spermatogenesis showed a mutually exclusive pattern, implying that Coxfa4 replaces Coxfa4l3 in Complex IV after meiosis. These results may provide some insight into the unique mechanism of ATP production in late spermatogenesis.

引用

页码：1 / 7

页数：7

共 39 条

[11]

Li JC, 2010, PLOS GENET, V6, DOI [10.1371/journal.pgen.1000795, 10.1186/1746-4811-6-1]

[12] The identification of induction chemo-sensitivity genes of laryngeal squamous cell carcinoma and their clinical utilization [J].

Li, Lianhe ;

Wang, Ru ;

He, Shizhi ;

Shen, Xixi ;

Kong, Fanyong ;

Li, Shuchun ;

Zhao, Huanhu ;

Lian, Meng ;

Fang, Jugao .

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 2018, 275 (11) :2773-2781

[13] miR-147, a microRNA that is induced upon Toll-like receptor stimulation, regulates murine macrophage inflammatory responses [J].

Liu, Gang ;

Friggeri, Arnaud ;

Yang, Yanping ;

Park, Young-Jun ;

Tsuruta, Yuko ;

Abraham, Edward .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (37) :15819-15824

[14] Integrated multi-omics characterization reveals a distinctive metabolic signature and the role of NDUFA4L2 in promoting angiogenesis, chemoresistance, and mitochondrial dysfunction in clear cell renal cell carcinoma [J].

Lucarelli, Giuseppe ;

Rutigliano, Monica ;

Sallustio, Fabio ;

Ribatti, Domenico ;

Giglio, Andrea ;

Signorile, Martina Lepore ;

Grossi, Valentina ;

Sanese, Paola ;

Napoli, Anna ;

Maiorano, Eugenio ;

Bianchi, Cristina ;

Perego, Roberto A. ;

Ferro, Matteo ;

Ranieri, Elena ;

Serino, Grazia ;

Bell, Lauren N. ;

Ditonno, Pasquale ;

Simone, Cristiano ;

Battaglia, Michele .

AGING-US, 2018, 10 (12) :3957-3985

[15] From Structure to Function: Mitochondrial Morphology, Motion and Shaping in Vascular Smooth Muscle [J].

McCarron, John G. ;

Wilson, Calum ;

Sandison, Mairi E. ;

Olson, Marnie L. ;

Girkin, John M. ;

Saunter, Christopher ;

Chalmers, Susan .

JOURNAL OF VASCULAR RESEARCH, 2013, 50 (05) :357-371

[16] Mitochondrial NDUFA4L2 protein promotes the vitality of lung cancer cells by repressing oxidative stress [J].

Meng, Lifei ;

Yang, Xuhui ;

Xie, Xiao ;

Wang, Mingsong .

THORACIC CANCER, 2019, 10 (04) :676-685

[17] The Enigma of the Respiratory Chain Supercomplex [J].

Milenkovic, Dusanka ;

Blaza, James N. ;

Larsson, Nils-Goeran ;

Hirst, Judy .

CELL METABOLISM, 2017, 25 (04) :765-776

[18] Cardiolipin-dependent formation of mitochondrial respiratory supercomplexes [J].

Mileykovskaya, Eugenia ;

Dowhan, William .

CHEMISTRY AND PHYSICS OF LIPIDS, 2014, 179 :42-48

[19] Cardiolipin membrane domains in prokaryotes and eukaryotes [J].

Mileykovskaya, Eugenia ;

Dowhan, William .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2009, 1788 (10) :2084-2091

[20] Effects of long-term low oxygen tension in human chondrosarcoma cells [J].

Piltti, Juha ;

Bygdell, Joakim ;

Qu, Chengjuan ;

Lammi, Mikko J. .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2018, 119 (02) :2320-2332

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