A pituitary adenoma secreting follicle-stimulating hormone with ovarian hyperstimulation: treatment using a gonadotropin-releasing hormone antagonist

被引：18
作者：
Garmes, Heraldo Mendes [1 ]
Grassiotto, Oswaldo Rocha [2 ]
Fernandes, Yvens Barbosa [3 ]
Queiroz, Luciano de Souza [4 ]
Vassalo, Jose [4 ]
de Oliveira, Daniel Minutti [1 ]
Benetti-Pinto, Cristina Laguna [2 ]
机构：
[1] Univ Estadual Campinas, UNICAMP, Sch Med, Dept Clin Med Endocrinol, Campinas, SP, Brazil
[2] Univ Estadual Campinas, UNICAMP, Sch Med, Dept Obstet & Gynecol, Campinas, SP, Brazil
[3] Univ Estadual Campinas, UNICAMP, Sch Med, Dept Neurol, Campinas, SP, Brazil
[4] Univ Estadual Campinas, UNICAMP, Sch Med, Dept Anatomopathol, Campinas, SP, Brazil
来源：
FERTILITY AND STERILITY | 2012年 / 97卷 / 01期
关键词：
FSH-secreting pituitary tumor; GnRH antagonist; pituitary adenoma; ovarian hyperstimulation syndrome; WOMAN;
D O I：
10.1016/j.fertnstert.2011.10.015
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: To describe the management of a patient with a pituitary adenoma secreting follicle-stimulating hormone (FSH) associated with ovarian hyperstimulation who was treated with a gonadotropin-releasing hormone (GnRH) antagonist. Design: Case report. Setting: University teaching hospital. Patient(s): A woman of reproductive age with secondary amenorrhea and ovarian hyperstimulation due to a pituitary adenoma secreting FSH, which persisted after transsphenoidal surgery. Intervention(s): Clinical treatment with a GnRH antagonist. Main Outcome Measure(s): A decrease in serum estradiol levels. Result(s): During the treatment period, ovarian hyperstimulation decreased as shown by a reduction in estradiol levels and an improvement in the patient's clinical condition and in the ultrasonography parameters. Conclusion(s): The GnRH antagonist was found to be effective for the short-term treatment of ovarian hyperstimulation secondary to a pituitary adenoma secreting FSH, thus representing a therapeutic option that should be taken into consideration in such cases. (Fertil Steril (R) 2012;97:231-4. (C) 2012 by American Society for Reproductive Medicine.)
引用
收藏
页码：231 / 234
页数：4
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