Diverse roles for semaphorin-plexin signaling in the immune system

被引：137

作者：

Takamatsu, Hyota ^{[1
,2
]}

Kumanogoh, Atsushi ^{[1
,2
]}

机构：

[1] Osaka Univ, Dept Immunopathol, WPI Immunol Frontier Res Ctr, Osaka, Japan

[2] Osaka Univ, Grad Sch Med, Dept Resp Med Allergy & Rheumat Dis, Osaka, Japan

来源：

TRENDS IN IMMUNOLOGY | 2012年 / 33卷 / 03期

基金：

日本科学技术振兴机构;

关键词：

GTPASE-ACTIVATING PROTEIN; T-CELL ACTIVATION; NONREDUNDANT ROLES; CRYSTAL-STRUCTURE; STRUCTURAL BASIS; DENDRITIC CELLS; B-CELL; SURFACE EXPRESSION; RECEPTOR PLEXIN-B1; TUMOR-CELLS;

D O I：

10.1016/j.it.2012.01.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Semaphorins were originally identified as axon guidance factors involved in the development of the neuronal system. However, accumulating evidence indicates that several semaphorins, so-called 'immune semaphorins', are crucially involved in various phases of both physiological and pathological immune responses; some regulate immune cell activation or differentiation, whereas others navigate the trafficking of immune cells. Plexin family members are one of the most representative semaphorin receptors and the semaphorin plexin complex structures were recently determined in crystallization studies. Here, we review the rapidly emerging functions of semaphorins and their receptors in the immune system.

引用

页码：127 / 135

页数：9

共 99 条

[41] The TIM gene family:: Emerging roles in immunity and disease [J].

Kuchroo, VK ;

Umetsu, DT ;

DeKruyff, RH ;

Freeman, GJ .

NATURE REVIEWS IMMUNOLOGY, 2003, 3 (06) :454-462

[42] Requirement for CD100-CD72 interactions in fine-tuning of B-cell antigen receptor signaling and homeostatic maintenance of the B-cell compartment [J].

Kumanogoh, A ;

Shikina, T ;

Watanabe, C ;

Takegahara, N ;

Suzuki, K ;

Yamamoto, M ;

Takamatsu, H ;

Prasad, DVR ;

Mizui, M ;

Toyofuku, T ;

Tamura, M ;

Watanabe, D ;

Parnes, JR ;

Kikutani, H .

INTERNATIONAL IMMUNOLOGY, 2005, 17 (10) :1277-1282

[43] Nonredundant roles of Sema4A in the immune system: Defective T cell priming and Th1/Th2 regulation in Sema4A-deficient mice [J].

Kumanogoh, A ;

Shikina, T ;

Suzuki, K ;

Uematsu, S ;

Yukawa, K ;

Kashiwamura, SI ;

Tsutsui, H ;

Yamamoto, M ;

Takamatsu, H ;

Ko-Mitamura, EP ;

Takegahara, N ;

Marukawa, S ;

Ishida, I ;

Morishita, H ;

Prasad, DVR ;

Tamura, M ;

Mizui, M ;

Toyofuku, T ;

Akira, S ;

Takeda, K ;

Okabe, M ;

Kikutani, H .

IMMUNITY, 2005, 22 (03) :305-316

[44] Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2 [J].

Kumanogoh, A ;

Marukawa, S ;

Suzuki, K ;

Takegahara, N ;

Watanabe, C ;

Ch'ng, ES ;

Ishida, I ;

Fujimura, H ;

Sakoda, S ;

Yoshida, K ;

Kikutani, H .

NATURE, 2002, 419 (6907) :629-633

[45] Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: A novel mechanism for regulating B cell signaling [J].

Kumanogoh, A ;

Watanabe, C ;

Lee, I ;

Wang, XS ;

Shi, W ;

Araki, H ;

Hirata, H ;

Iwahori, K ;

Uchida, J ;

Yasui, T ;

Matsumoto, M ;

Yoshida, K ;

Yakura, H ;

Pan, C ;

Parnes, JR ;

Kikutani, H .

IMMUNITY, 2000, 13 (05) :621-631

[46] Rapid leukocyte migration by integrin-independent flowing and squeezing [J].

Laemmermann, Tim ;

Bader, Bernhard L. ;

Monkley, Susan J. ;

Worbs, Tim ;

Wedlich-Soeldner, Roland ;

Hirsch, Karin ;

Keller, Markus ;

Foerster, Reinhold ;

Critchley, David R. ;

Faessler, Reinhard ;

Sixt, Michael .

NATURE, 2008, 453 (7191) :51-+

[47] Structural Basis of Semaphorin-Plexin Recognition and Viral Mimicry from Sema7A and A39R Complexes with PlexinC1 [J].

Liu, Heli ;

Juo, Z. Sean ;

Shim, Ann Hye-Ryong ;

Focia, Pamela J. ;

Chen, Xiaoyan ;

Garcia, K. Christopher ;

He, Xiaolin .

CELL, 2010, 142 (05) :749-761

[48] The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D [J].

Love, CA ;

Harlos, K ;

Mavaddat, N ;

Davis, SJ ;

Stuart, DI ;

Jones, EY ;

Esnouf, RM .

NATURE STRUCTURAL BIOLOGY, 2003, 10 (10) :843-848

[49] Involvement of Sema4A in the progression of experimental autoimmune myocarditis [J].

Makino, Nobuhiko ;

Toyofuku, Toshihiko ;

Takegahara, Noriko ;

Takamatsu, Hyota ;

Okuno, Tatsusada ;

Nakagawa, Yukinobu ;

Kang, Sujin ;

Nojima, Satoshi ;

Hori, Masatsugu ;

Kikutani, Hitoshi ;

Kumanogoh, Atsushi .

FEBS LETTERS, 2008, 582 (28) :3935-3940

[50] Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling [J].

Mitsui, N ;

Inatome, R ;

Takahashi, S ;

Goshima, Y ;

Yamamura, H ;

Yanagi, S .

EMBO JOURNAL, 2002, 21 (13) :3274-3285

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