Highly Biocompatible Drug-Delivery Systems Based on DNA Nanotechnology

被引：19

作者：

Li, Xin ^{[1
]}

Hong, Li ^{[1
]}

Song, Tao ^{[2
,3
]}

Rodriguez-Paton, Alfonso ^{[3
]}

Chen, Congzhou ^{[4
]}

Zhao, Haiyan ^{[4
]}

Shi, Xiaolong ^{[4
]}

机构：

[1] Wuhan Univ, Renmin Hosp, Dept Gynecol 2, Wuhan 430060, Hubei, Peoples R China

[2] China Univ Petr, Coll Comp & Commun Engn, Qingdao 266580, Shandong, Peoples R China

[3] Univ Politecn Madrid, Dept Inteligencia Artificial, E-28660 Madrid, Spain

[4] Huazhong Univ Sci & Technol, Sch Automat, Key Lab Image Informat Proc & Intelligent Control, Wuhan 430074, Hubei, Peoples R China

来源：

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | 2017年 / 13卷 / 07期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

DNA Nanostructure; DNA Origami; Drug-Delivery System; Nanotechnology; IN-VIVO; CANCER-THERAPY; BIOMEDICAL APPLICATIONS; CELLULAR DELIVERY; SIRNA DELIVERY; BREAST-CANCER; ORIGAMI; CELLS; NANOSTRUCTURES; NANOPARTICLES;

D O I：

10.1166/jbn.2017.2383

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Nanotechnology has been widely used in pharmacology and medicine, particularly for developing methods to enhance drug bioavailability and reduce the toxic side effects of drugs, and has given rise to the "nano drug-delivery system." Recent work has demonstrated that DNA nanostructures, which can efficiently penetrate cells and are highly biocompatible, hold considerable potential for use in designing effective nano drug-delivery systems. Here, we briefly review the advantages offered by DNA nanostructures for drug delivery, the various types of currently available drug-delivery systems based on DNA nanostructures, and the cellular uptake of DNA nanostructures.

引用

页码：747 / 757

页数：11

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