Effect of Exposure of Human Monocyte-Derived Macrophages to High, versus Normal, Glucose on Subsequent Lipid Accumulation from Glycated and Acetylated Low-Density Lipoproteins

被引:11
|
作者
Moheimani, Fatemeh [1 ,2 ]
Tan, Joanne T. M. [3 ]
Brown, Bronwyn E. [1 ]
Heather, Alison K. [3 ]
van Reyk, David M. [4 ]
Davies, Michael J. [1 ,2 ]
机构
[1] Heart Res Inst, Free Rad Grp, Sydney, NSW 2042, Australia
[2] Univ Sydney, Fac Med, Sydney, NSW 2006, Australia
[3] Heart Res Inst, Gene Regulat Grp, Sydney, NSW 2042, Australia
[4] Univ Technol Sydney, Sch Med & Mol Biosci, Sydney, NSW 2007, Australia
基金
英国医学研究理事会; 澳大利亚研究理事会;
关键词
A SCAVENGER RECEPTORS; FOAM CELL-FORMATION; IN-VITRO FORMATION; END-PRODUCTS; PHYSIOLOGICAL CONDITIONS; DIABETIC COMPLICATIONS; CARDIOVASCULAR-DISEASE; CHOLESTEROL TRANSPORT; INHIBIT GLYCATION; MAILLARD REACTION;
D O I
10.1155/2011/851280
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
During atherosclerosis monocyte-derived macrophages accumulate cholesteryl esters from low-density lipoproteins (LDLs) via lectin-like oxidised LDL receptor-1 (LOX-1) and class AI and AII (SR-AI, SR-AII) and class B (SR-BI, CD36) scavenger receptors. Here we examined the hypothesis that hyperglycaemia may modulate receptor expression and hence lipid accumulation in macrophages. Human monocytes were matured into macrophages in 30 versus 5 mM glucose and receptor expression and lipid accumulation quantified. High glucose elevated LOX1 mRNA, but decreased SR-AI, SR-BI, LDLR, and CD36 mRNA. SR-BI and CD36 protein levels were decreased. Normo- and hyperglycaemic cells accumulated cholesteryl esters from modified LDL to a greater extent than control LDL, but total and individual cholesteryl ester accumulation was not affected by glucose levels. It is concluded that, whilst macrophage scavenger receptor mRNA and protein levels can be modulated by high glucose, these are not key factors in lipid accumulation by human macrophages under the conditions examined.
引用
收藏
页数:10
相关论文
共 50 条
  • [1] COMPARATIVE INTERACTION OF GLYCATED AND OXIDIZED LOW-DENSITY LIPOPROTEINS WITH HUMAN MONOCYTE-DERIVED MACROPHAGES
    GUGLIUCCI, A
    SIFFERT, JC
    DUMONT, S
    STAHL, AJC
    INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 1993, 6 (01) : 51 - 57
  • [2] METABOLISM OF ACETYLATED LOW-DENSITY LIPOPROTEINS BY MONOCYTE-DERIVED MACROPHAGES FROM PATIENTS WITH WERNERS SYNDROME
    MORI, S
    MORISAKI, N
    SAITO, Y
    YOSHIDA, S
    ARTERIOSCLEROSIS, 1989, 9 (05): : 644 - 649
  • [3] SIMVASTATIN INHIBITS THE OXIDATION OF LOW-DENSITY LIPOPROTEINS BY ACTIVATED HUMAN MONOCYTE-DERIVED MACROPHAGES
    GIROUX, LM
    DAVIGNON, J
    NARUSZEWICZ, M
    BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1165 (03) : 335 - 338
  • [4] SIMVASTATIN INHIBITS THE OXIDATION OF LOW-DENSITY LIPOPROTEINS BY ACTIVATED HUMAN MONOCYTE-DERIVED MACROPHAGES
    GIROUX, LM
    PARE, E
    DAVIGNON, J
    NARUSZEWICZ, M
    CIRCULATION, 1992, 86 (04) : 212 - 212
  • [5] MONOCYTE COLONY-STIMULATING FACTOR ENHANCES UPTAKE AND DEGRADATION OF ACETYLATED LOW-DENSITY LIPOPROTEINS AND CHOLESTEROL ESTERIFICATION IN HUMAN MONOCYTE-DERIVED MACROPHAGES
    ISHIBASHI, S
    INABA, T
    SHIMANO, H
    HARADA, K
    INOUE, I
    MOKUNO, H
    MORI, N
    GOTODA, T
    TAKAKU, F
    YAMADA, N
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1990, 265 (24) : 14109 - 14117
  • [6] STIMULATION OF CHOLESTERYL ESTER SYNTHESIS IN HUMAN MONOCYTE-DERIVED MACROPHAGES BY ASIALO LOW-DENSITY LIPOPROTEINS
    TANIGUCHI, T
    ISHIKAWA, Y
    TSUNEMITSU, M
    ASAOKA, Y
    MATSUMOTO, K
    FUKUZAKI, H
    ARTERIOSCLEROSIS, 1989, 9 (05): : A767 - A767
  • [7] DEGRADATION BY CULTURED MONOCYTE-DERIVED MACROPHAGES FROM NORMAL AND FAMILIAL HYPERCHOLESTEROLEMIC SUBJECTS OF MODIFIED AND UNMODIFIED LOW-DENSITY LIPOPROTEINS
    SOUTAR, AK
    KNIGHT, BL
    BIOCHEMICAL JOURNAL, 1982, 204 (02) : 549 - 556
  • [8] STIMULATION OF CHOLESTERYL ESTER SYNTHESIS IN HUMAN MONOCYTE-DERIVED MACROPHAGES BY LOW-DENSITY LIPOPROTEINS FROM TYPE-1 (INSULIN-DEPENDENT) OF LOW-DENSITY LIPOPROTEINS
    LYONS, TJ
    KLEIN, RL
    BAYNES, JW
    STEVENSON, HC
    LOPESVIRELLA, MF
    DIABETOLOGIA, 1987, 30 (12) : 916 - 923
  • [9] LOCALIZATION OF THE BINDING-SITES OF NATIVE AND ACETYLATED LOW-DENSITY LIPOPROTEIN (LDL) IN HUMAN MONOCYTE-DERIVED MACROPHAGES
    TRABER, MG
    KALLMAN, B
    KAYDEN, HJ
    EXPERIMENTAL CELL RESEARCH, 1983, 148 (02) : 281 - 292
  • [10] INVITRO GLYCATED LOW-DENSITY-LIPOPROTEIN INTERACTION WITH HUMAN MONOCYTE-DERIVED MACROPHAGES
    CRERICHE, AG
    DUMONT, S
    SIFFERT, JC
    STAHL, AJC
    RESEARCH IN IMMUNOLOGY, 1992, 143 (01): : 17 - 23