Evaluation of susceptibility locus for response to interferon-α based therapy in chronic hepatitis B patients in Chinese

被引：40

作者：

Wu, Xiaopan ^{[1
]}

Xin, Zhenhui ^{[1
]}

Zhu, Xilin ^{[1
]}

Pan, Liping ^{[1
]}

Li, Zhuo ^{[2
]}

Li, Hui ^{[3
]}

Liu, Ying ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Inst Basic Med Sci, Peking Union Med Coll,Sch Basic Med, Natl Lab Med Mol Biol,Inst Basic Med Sci, Beijing 100005, Peoples R China

[2] Capital Univ Med Sci, Youan Hosp, Dept Infect Dis, Beijing, Peoples R China

[3] Chinese Acad Med Sci, Inst Basic Med Sci, Peking Union Med Coll, Dept Epidemiol,Sch Basic Med, Beijing 100005, Peoples R China

来源：

ANTIVIRAL RESEARCH | 2012年 / 93卷 / 02期

基金：

国家高技术研究发展计划(863计划);

关键词：

Chronic hepatitis B; Interferon-alpha therapy; Single nucleotide polymorphism; Interleukin 28B gene; Sustained virologic response; C VIRUS-INFECTION; GENETIC POLYMORPHISMS; PLUS RIBAVIRIN; IL28B; ASSOCIATION; MANAGEMENT; CLEARANCE; MXA;

D O I：

10.1016/j.antiviral.2011.12.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In 2009, three independent genome-wide association studies reported that genetic variation in the interleukin 28B gene to be associated with the response to interferon-alpha/ribavirin therapy in hepatitis C virus genotype 1 infected patients. We carried out the present study to assess whether such polymorphisms also affect the therapy effect of another interferon-alpha responsive illness as chronic hepatitis B. Five hundred and twelve interferon-alpha treatment-naive HBeAg seropositive chronic hepatitis B patients were enrolled in the present retrospective nested case-control study. All patients received PEG-IFN-alpha-2a based treatment and were examined for the therapy efficacy. SNP rs8099917 was genotyped using the Mass-Array system (Sequenom). Interestingly, the frequency of G allele of rs8099917 was significantly higher in response group than in non response group (8.3% vs. 3.9%, p = 0.003, OR = 0.44, 95%CI = 0.25-0.79). The genotype distributions of this SNP also differed significantly between two groups (p = 0.003). Our study suggested that the G allele of rs8099917 was associated with higher rate of response in HBeAg seropositive chronic hepatitis B patients treated with interferon alpha. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：297 / 300

页数：4