Hypoglycemic and hypolipidemic effects of aqueous extract of phaseolus vulgaris pods in streptozotocin-diabetic rats

被引：12

作者：

Almuaigel, Mohammad Faisal ^{[1
]}

Seif, Mosaad A. ^{[2
]}

Albuali, Hamad Waleed ^{[1
]}

Alharbi, Omar ^{[1
]}

Alhawash, Amer ^{[1
]}

机构：

[1] King Faisal Univ, Coll Med, Alahsaa, Saudi Arabia

[2] King Faisal Univ, Coll Med, Dept Biochem, Alahsaa, Saudi Arabia

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2017年 / 94卷

关键词：

Hypoglycemic; Hypolipidemic; Phaseolus vulgaris pods; Saudi Arabia; Diabetes; ANTIDIABETIC ACTIVITY; MELLITUS; DISEASE; MICE; L;

D O I：

10.1016/j.biopha.2017.07.135

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The present investigation was carried out to evaluate the reduction potential of aqueous extract of casing of pods of phaseolus vulgaris in blood glucose and lipids levels among hyperglycemic streptozotocin (STZ)-induced rats. Oral administration of 150 mg/kg of aqueous oral administration of aqueous pod extract of phaseolus vulgaris to diabetic rats for 40 days resulted in a significant decrease in blood glucose (p < 001), cholesterol (P < 0.01) and triglycerides (P < 0.01). In addition, glibenclamide reduced blood glucose, cholesterol and triglycerides. It is concluded that both aqueous extract of casing of pods of phaseolus vulgaris and glibenclamide reduced the blood levels of glucose and lipids. In addition, aqueous extract of phaseolus vulgaris pods was more effective than glibenclamide in reducing blood glucose. (C) 2017 Elsevier Masson SAS. All rights reserved.

引用

页码：742 / 746

页数：5

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