Anti-plasmodial activity of Ailanthus excelsa

被引：10

作者：

Dell'Agli, Mario ^{[1
]}

Galli, Gennana V. ^{[1
]}

Parapini, Silvia ^{[2
]}

Basilico, Nicoletta ^{[2
]}

Taramelli, Donatella ^{[2
]}

Said, Ataa ^{[3
]}

Rashed, Khaled ^{[3
]}

Bosisio, Enrica ^{[1
]}

机构：

[1] Univ Milan, Dept Pharmacol Sci, Milan, Italy

[2] Univ Milan, Dept Publ Hlth Microbiol & Virol, Milan, Italy

[3] Natl Res Ctr, Dept Pharmacognosy, Giza, Egypt

来源：

FITOTERAPIA | 2008年 / 79卷 / 02期

关键词：

Ailanthus excelsa; malaria; anti-plasmodial activity; plasmepsins; haemozoin;

D O I：

10.1016/j.fitote.2007.11.003

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The anti-plasmodial activity of Ailanthus excelsa stem bark was investigated. The methanolic extract inhibited in vitro growth of chloroquine-sensitive (D10) and resistant strains (W2) of Plasmodium falciparum (IC50 4.6 and 2.8 mu g/ml, respectively). The effect was retained in the chloroform fraction (3.1 and 2.1 mu g/ml, respectively). The anti-plasmodial activity could be ascribed to the impairment of haemoglobin degradation through the inhibition of plasmepsin II activity (IC50 of 13.43 +/- 1.74 mu g/ml) and of the haem detoxification to haemozoin. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：112 / 116

页数：5

共 30 条

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