Novel Mutations in a Patient Isolate of Streptococcus agalactiae with Reduced Penicillin Susceptibility Emerging after Long-Term Oral Suppressive Therapy

被引：74

作者：

Longtin, Jean ^{[1
,2
]}

Vermeiren, Christie ^{[3
,4
]}

Shahinas, Dea ^{[2
,4
]}

Tamber, Gurdip Singh ^{[2
,4
]}

McGeer, Allison ^{[4
,5
]}

Low, Donald E. ^{[2
,4
,5
]}

Katz, Kevin ^{[3
,4
,6
]}

Pillai, Dylan R. ^{[2
,4
]}

机构：

[1] Ctr Hosp Univ Quebec, Quebec City, PQ G1V 4G2, Canada

[2] Ontario Agcy Hlth Protect & Promot, Toronto, ON, Canada

[3] Shared Hosp Lab, Toronto, ON, Canada

[4] Univ Toronto, Toronto, ON, Canada

[5] Mt Sinai Hosp, Toronto, ON M5G 1X5, Canada

[6] N York Gen Hosp, Toronto, ON, Canada

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 06期

关键词：

GROUP-B STREPTOCOCCI; MOLECULAR CHARACTERIZATION; DECREASED SUSCEPTIBILITY; RESISTANCE;

D O I：

10.1128/AAC.01243-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Penicillin nonsusceptibility has been demonstrated in group B streptococci (GBS), but there is limited information regarding mechanisms of resistance. We report a case of GBS with reduced susceptibility to penicillin emerging after long-term suppressive oral penicillin therapy for a prosthetic joint infection. Molecular characterization of the isolate before and after long-term penicillin therapy revealed 5 mutations in the ligand-binding regions of PBP1a, -2a, and -2x not previously reported in GBS.

引用

页码：2983 / 2985

页数：3

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