Chiral Heterodisulfoxide Ligands in Rhodium-Catalyzed Asymmetric 1,4-Addition of Arylboronic Acids to Chromenones

被引：43

作者：

Han, Fuzhong ^{[1
,2
,3
]}

Chen, Guihua ^{[1
,2
,3
]}

Zhang, Xiangyang ^{[1
,2
,3
]}

Liao, Jian ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, Chengdu Inst Organ Chem, Key Lab Asymmetr Synth & Chirotechnol Sichuan Pro, Chengdu 610041, Peoples R China

[2] Chinese Acad Sci, Chengdu Inst Biol, Nat Prod Ctr, Chengdu 610041, Peoples R China

[3] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 2011卷 / 16期

基金：

中国国家自然科学基金;

关键词：

Sulfur; Ligand design; Chromenones; Boron; Michael addition; BIS-SULFOXIDE LIGAND; ENANTIOSELECTIVE SYNTHESIS; FLAVANONES; 2'-HYDROXYCHALCONES; PERSPECTIVES; CONVERSION; ESTERS;

D O I：

10.1002/ejoc.201100387

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new family of benzene-based chiral heterodisulfoxide ligands L1-L5 was synthesized in a single step. These disulfoxide ligands were applied in the rhodium-catalyzed asymmetric 1,4-addition of arylboronic acids to chromenones. The addition of diverse arylboronic acids to chromenones proceeds smoothly in up to 70% yield with up to 95% ee.

引用

页码：2928 / 2931

页数：4

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