Ursolic Acid Suppresses Interleukin-17 (IL-17) Production by Selectively Antagonizing the Function of RORλt Protein

被引：190

作者：

Xu, Tao ^{[1
]}

Wang, Xiaohu ^{[2
,3
]}

Zhong, Bo ^{[2
,3
]}

Nurieva, Roza I. ^{[2
,3
]}

Ding, Sheng ^{[1
]}

Dong, Chen ^{[2
,3
]}

机构：

[1] Univ Calif San Francisco, Gladstone Inst Cardiovasc Dis, Dept Pharmaceut Chem, San Francisco, CA 94158 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA

[3] Univ Texas MD Anderson Canc Ctr, Ctr Inflammat & Canc, Houston, TX 77030 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2011年 / 286卷 / 26期

基金：

美国国家卫生研究院;

关键词：

GROWTH-FACTOR-BETA; GAMMA-T; TH17; CELLS; DIFFERENTIATION; LINEAGE; ALPHA; EXPRESSION; DISTINCT;

D O I：

10.1074/jbc.C111.250407

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Th17 cells have recently emerged as a major player in inflammatory and autoimmune diseases via the production of pro-inflammatory cytokines IL-17, IL-17F, and IL-22. The differentiation of Th17 cells and the associated cytokine production is directly controlled by ROR gamma t. Here we show that ursolic acid (UA), a small molecule present in herbal medicine, selectively and effectively inhibits the function of ROR gamma t, resulting in greatly decreased IL-17 expression in both developing and differentiated Th17 cells. In addition, treatment with UA ameliorated experimental autoimmune encephalomyelitis. The results thus suggest UA as a valuable drug candidate or leading compound for developing treatments of Th17-mediated inflammatory diseases and cancer.

引用

页码：22707 / 22710

页数：4

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