Maternal salivary cortisol differs by fetal sex during the second half of pregnancy

被引：75

作者：

DiPietro, Janet A. ^{[1
]}

Costigan, Kathleen A. ^{[2
]}

Kivlighan, Katie T. ^{[1
]}

Chen, Ping ^{[3
]}

Laudenslager, Mark L. ^{[4
]}

机构：

[1] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Populat Family & Reprod Hlth, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Gynecol & Obstet, Div Maternal Fetal Med, Baltimore, MD 21205 USA

[3] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD 21205 USA

[4] Univ Colorado, Hlth Sci Ctr, Dept Psychiat, Denver, CO 80220 USA

来源：

PSYCHONEUROENDOCRINOLOGY | 2011年 / 36卷 / 04期

关键词：

Cortisol; Pregnancy; Sex differences; Male vulnerability; HPA axis; STRESS; EXPOSURE;

D O I：

10.1016/j.psyneuen.2010.09.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Maternal salivary cortisol was measured at weekly intervals from 24 to 38 weeks gestation. The total sample consisted of 120 women enrolled in staggered intervals in such a way as to generate weekly measures of salivary cortisol during the latter half of pregnancy. Hierarchical linear modeling revealed the expected increase in unbound maternal cortisol during this period, with a slight deceleration in rate of increase at 33 weeks gestation. Women carrying male fetuses had higher levels of salivary cortisol initially as compared to women carrying female fetuses; at 30 weeks gestation there was cross-over such that higher maternal cortisol was observed in women carrying female fetuses beyond this time and through term. Results highlight the importance of considering fetal sex as a moderator of contemporaneous and predictive associations between maternal cortisol and prenatal or postnatal development. (c) 2010 Elsevier Ltd. All rights reserved.

引用

页码：588 / 591

页数：4

共 14 条

[1] Maturation of the human fetal startle response: Evidence for sex-specific maturation of the human fetus [J].

Buss, Claudia ;

Davis, Elysia Poggi ;

Class, Quetzal A. ;

Gierczak, Matt ;

Pattillo, Carol ;

Glynn, Laura M. ;

Sandman, Curt A. .

EARLY HUMAN DEVELOPMENT, 2009, 85 (10) :633-638

[2] Sex and the Human Placenta: Mediating Differential Strategies of Fetal Growth and Survival [J].

Clifton, V. L. .

PLACENTA, 2010, 31 :S33-S39

[3] Characterization of human fetal cord blood steroid profiles in relation to fetal sex and mode of delivery using temperature-dependent inclusion chromatography and principal component analysis (PCA) [J].

Clifton, Vicki L. ;

Bisits, Andrew ;

Zarzycki, Pawel K. .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2007, 855 (02) :249-254

[4] The Timing of Prenatal Exposure to Maternal Cortisol and Psychosocial Stress Is Associated With Human Infant Cognitive Development [J].

Davis, Elysia P. ;

Sandman, Curt A. .

CHILD DEVELOPMENT, 2010, 81 (01) :131-148

[5] Sex differences in the relation between prenatal maternal emotional complaints and child outcome [J].

de Bruijn, Anouk T. C. E. ;

van Bakel, Hedwig J. A. ;

van Baar, Anneloes L. .

EARLY HUMAN DEVELOPMENT, 2009, 85 (05) :319-324

[6] Prenatal Antecedents of Newborn Neurological Maturation [J].

DiPietro, Janet A. ;

Kivlighan, Katie T. ;

Costigan, Kathleen A. ;

Rubin, Suzanne E. ;

Shiffler, Dorothy E. ;

Henderson, Janice L. ;

Pillion, Joseph P. .

CHILD DEVELOPMENT, 2010, 81 (01) :115-130

[7] Fetal Motor Activity and Maternal Cortisol [J].

DiPietro, Janet A. ;

Kivlighan, Katie T. ;

Costigan, Kathleen A. ;

Laudenslager, Mark L. .

DEVELOPMENTAL PSYCHOBIOLOGY, 2009, 51 (06) :505-512

[8] Timing of fetal exposure to stress hormones: Effects on newborn physical and neuromuscular maturation [J].

Ellman, Lauren M. ;

Schetter, Christine Dunkel ;

Hobel, Calvin J. ;

Chicz-DeMet, Aleksandra ;

Glynn, Laura M. ;

Sandman, Curt A. .

DEVELOPMENTAL PSYCHOBIOLOGY, 2008, 50 (03) :232-241

[9] AN IMMUNOREACTIVE THEORY OF SELECTIVE MALE AFFLICTION [J].

GUALTIERI, T ;

HICKS, RE .

BEHAVIORAL AND BRAIN SCIENCES, 1985, 8 (03) :427-441

[10] Diurnal rhythm of cortisol during late pregnancy: Associations with maternal psychological well-being and fetal growth [J].

Kivlighan, Katie T. ;

DiPietro, Janet A. ;

Costigan, Kathleen A. ;

Laudenslager, Mark L. .

PSYCHONEUROENDOCRINOLOGY, 2008, 33 (09) :1225-1235

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