The first Japanese biobank of patient-derived pediatric acute lymphoblastic leukemia xenograft models

被引：5

作者：

Tanaka, Kuniaki ^{[1
]}

Kato, Itaru ^{[1
,2
]}

Dobashi, Yuu ^{[3
]}

Imai, Jun-ichi ^{[3
]}

Mikami, Takashi ^{[1
]}

Kubota, Hirohito ^{[1
]}

Ueno, Hiroo ^{[1
,4
]}

Ito, Mamoru ^{[5
]}

Ogawa, Seishi ^{[4
]}

Nakahata, Tatsutoshi ^{[5
,6
]}

Takita, Junko ^{[1
]}

Toyoda, Hidemi ^{[2
,7
]}

Ogawa, Chitose ^{[2
,8
]}

Adachi, Souichi ^{[9
]}

Watanabe, Shinya ^{[3
]}

Goto, Hiroaki ^{[2
,10
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Pediat, Kyoto, Japan

[2] Relapsed All Comm, Japan Childrens Canc Grp, Nagoya, Aichi, Japan

[3] Fukushima Med Univ, Med Ind Translat Res Ctr, Fukushima, Japan

[4] Kyoto Univ, Grad Sch Med, Dept Pathol & Tumor Biol, Kyoto, Japan

[5] Cent Inst Expt Anim, Kawasaki, Kanagawa, Japan

[6] Kyoto Univ, Dept Fundamental Cell Technol, Ctr iPS Cell Res & Applicat, Kyoto, Japan

[7] Mie Univ, Dept Pediat, Grad Sch Med, Tsu, Mie, Japan

[8] Natl Canc Ctr, Dept Pediat Oncol, Tokyo, Japan

[9] Kyoto Univ, Grad Sch Med, Dept Human Hlth Sci, Kyoto, Japan

[10] Kanagawa Childrens Med Ctr, Div Hematol Oncol, Yokohama, Kanagawa, Japan

来源：

CANCER SCIENCE | 2022年 / 113卷 / 11期

关键词：

biobank; leukemia; pediatric; preclinical; xenograft; VIVO CANCER MODELS; MOUSE; HETEROGENEITY; CHILDREN;

D O I：

10.1111/cas.15506

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A lack of practical resources in Japan has limited preclinical discovery and testing of therapies for pediatric relapsed and refractory acute lymphoblastic leukemia (ALL), which has poor outcomes. Here, we established 57 patient-derived xenografts (PDXs) in NOD.Cg-Prkdc(scid)ll2rg(tm1Sug)/ShiJic (NOG) mice and created a biobank by preserving PDX cells including three extramedullary relapsed ALL PDXs. We demonstrated that our PDX mice and PDX cells mimicked the biological features of relapsed ALL and that PDX models reproduced treatment-mediated clonal selection. Our PDX biobank is a useful scientific resource for capturing drug sensitivity features of pediatric patients with ALL, providing an essential tool for the development of targeted therapies.

引用

页码：3814 / 3825

页数：12

共 42 条

[1] Clonal selection and asymmetric distribution of human leukemia in murine xenografts revealed by cellular barcoding [J].

Belderbos, Mirjam E. ;

Koster, Taco ;

Ausema, Bertien ;

Jacobs, Sabrina ;

Sowdagar, Sharlaine ;

Zwart, Erik ;

de Bont, Eveline ;

de Haan, Gerald ;

Bystrykh, Leonid V. .

BLOOD, 2017, 129 (24) :3210-3220

[2] Patient-derived xenografts undergo mouse-specific tumor evolution [J].

Ben-David, Uri ;

Ha, Gavin ;

Tseng, Yuen-Yi ;

Greenwald, Noah F. ;

Oh, Coyin ;

Shih, Juliann ;

McFarland, James M. ;

Wong, Bang ;

Boehm, Jesse S. ;

Beroukhim, Rameen ;

Golub, Todd R. .

NATURE GENETICS, 2017, 49 (11) :1567-+

[3] A biobank of patient-derived pediatric brain tumor models [J].

Brabetz, Sebastian ;

Leary, Sarah E. S. ;

Groebner, Susanne N. ;

Nakamoto, Madison W. ;

Seker-Cin, Huriye ;

Girard, Emily J. ;

Cole, Bonnie ;

Strand, Andrew D. ;

Bloom, Karina L. ;

Hovestadt, Volker ;

Mack, Norman L. ;

Pakiam, Fiona ;

Schwalm, Benjamin ;

Korshunov, Andrey ;

Balasubramanian, Gnana Prakash ;

Northcott, Paul A. ;

Pedro, Kyle D. ;

Dey, Joyoti ;

Hansen, Stacey ;

Ditzler, Sally ;

Lichter, Peter ;

Chavez, Lukas ;

Jones, David T. W. ;

Koster, Jan ;

Pfister, Stefan M. ;

Kool, Marcel ;

Olson, James M. .

NATURE MEDICINE, 2018, 24 (11) :1752-+

[4] A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds [J].

Bruna, Alejandra ;

Rueda, Oscar M. ;

Greenwood, Wendy ;

Batra, Ankita Sati ;

Callari, Maurizio ;

Batra, Rajbir Nath ;

Pogrebniak, Katherine ;

Sandoval, Jose ;

Cassidy, John W. ;

Tufegdzic-Vidakovic, Ana ;

Sammut, Stephen-John ;

Jones, Linda ;

Provenzano, Elena ;

Baird, Richard ;

Eirew, Peter ;

Hadfield, James ;

Eldridge, Matthew ;

McLaren-Douglas, Anne ;

Barthorpe, Andrew ;

Lightfoot, Howard ;

O'Connor, Mark J. ;

Gray, Joe ;

Cortes, Javier ;

Baselga, Jose ;

Marangoni, Elisabetta ;

Welm, Alana L. ;

Aparicio, Samuel ;

Serra, Violeta ;

Garnett, Mathew J. ;

Caldas, Carlos .

CELL, 2016, 167 (01) :260-+

[5] A multicenter clinical study: personalized medication for advanced gastrointestinal carcinomas with the guidance of patient-derived tumor xenograft (PDTX) [J].

Cheng, Yuan ;

Qin, Shu-kui ;

Li, Jin ;

Dai, Guang-hai ;

Shen, Bai-yong ;

Ying, Jie-er ;

Ba, Yi ;

Liang, Han ;

Wang, Xin-bo ;

Xu, Ye ;

Zhou, Lin ;

Ding, Ke-feng ;

Qin, Yan-ru ;

Yang, Shu-jun ;

Guan, Wen-xian ;

Zheng, Hui ;

Wang, Qian ;

Song, Hang ;

Zhu, Yan-ping .

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2022, 148 (03) :673-684

[6] Inhibition of MEK and ATR is effective in a B-cell acute lymphoblastic leukemia model driven by Mll-Af4 and activated Ras [J].

Chu, S. Haihua ;

Song, Evelyn J. ;

Chabon, Jonathan R. ;

Minehart, Janna ;

Matovina, Chloe N. ;

Makofske, Jessica L. ;

Frank, Elizabeth S. ;

Ross, Kenneth ;

Koche, Richard P. ;

Feng, Zhaohui ;

Xu, Haiming ;

Krivtsov, Andrei ;

Nussenzweig, Andre ;

Armstrong, Scott A. .

BLOOD ADVANCES, 2018, 2 (19) :2478-2490

[7] PDX Finder: A portal for patient-derived tumor xenograft model discovery [J].

Conte, Nathalie ;

Mason, Jeremy C. ;

Halmagyi, Csaba ;

Neuhauser, Steven ;

Mosaku, Abayomi ;

Yordanova, Galabina ;

Chatzipli, Aikaterini ;

Begley, Dale A. ;

Krupke, Debra M. ;

Parkinson, Helen ;

Meehan, Terrence F. ;

Bult, Carol C. .

NUCLEIC ACIDS RESEARCH, 2019, 47 (D1) :D1073-D1079

[8] Dynamic changes in clonal cytogenetic architecture during progression of chronic lymphocytic leukemia in patients and patient-derived murine xenografts [J].

Davies, Nicholas J. ;

Kwok, Marwan ;

Gould, Clive ;

Oldreive, Ceri E. ;

Mao, Jingwen ;

Parry, Helen ;

Smith, Edward ;

Agathanggelou, Angelo ;

Pratt, Guy ;

Taylor, Alexander Malcolm R. ;

Moss, Paul ;

Griffiths, Mike ;

Stankovic, Tatjana .

ONCOTARGET, 2017, 8 (27) :44749-44760

[9] STAR: ultrafast universal RNA-seq aligner [J].

Dobin, Alexander ;

Davis, Carrie A. ;

Schlesinger, Felix ;

Drenkow, Jorg ;

Zaleski, Chris ;

Jha, Sonali ;

Batut, Philippe ;

Chaisson, Mark ;

Gingeras, Thomas R. .

BIOINFORMATICS, 2013, 29 (01) :15-21

[10] High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response [J].

Gao, Hui ;

Korn, Joshua M. ;

Ferretti, Stephane ;

Monahan, John E. ;

Wang, Youzhen ;

Singh, Mallika ;

Zhang, Chao ;

Schnell, Christian ;

Yang, Guizhi ;

Zhang, Yun ;

Balbin, O. Alejandro ;

Barbe, Stephanie ;

Cai, Hongbo ;

Casey, Fergal ;

Chatterjee, Susmita ;

Chiang, Derek Y. ;

Chuai, Shannon ;

Cogan, Shawn M. ;

Collins, Scott D. ;

Dammassa, Ernesta ;

Ebel, Nicolas ;

Embry, Millicent ;

Green, John ;

Kauffmann, Audrey ;

Kowa, Colleen ;

Leary, Rebecca J. ;

Lehar, Joseph ;

Liang, Ying ;

Loo, Alice ;

Lorenzana, Edward ;

McDonald, E. Robert, III ;

McLaughlin, Margaret E. ;

Merkin, Jason ;

Meyer, Ronald ;

Naylor, Tara L. ;

Patawaran, Montesa ;

Reddy, Anupama ;

Roeelli, Claudia ;

Ruddy, David A. ;

Salangsang, Fernando ;

Santacroce, Francesca ;

Singh, Angad P. ;

Tang, Yan ;

Tinetto, Walter ;

Tobler, Sonja ;

Velazquez, Roberto ;

Venkatesan, Kavitha ;

Von Arx, Fabian ;

Wang, Hui Qin ;

Wang, Zongyao .

NATURE MEDICINE, 2015, 21 (11) :1318-1325

← 1 2 3 4 5 →