Vesiclepedia 2019:a compendium of RNA, proteins, lipids and metabolites in extracellular vesicles

被引：576

作者：

Pathan, Mohashin ^{[1
]}

Fonseka, Pamali ^{[1
]}

Chitti, Sai V. ^{[1
]}

Kang, Taeyoung ^{[1
]}

Sanwlani, Rahul ^{[1
]}

Van Deun, Jan ^{[2
]}

Hendrix, An ^{[2
]}

Mathivanan, Suresh ^{[1
]}

机构：

[1] La Trobe Univ, Dept Biochem & Genet, La Trobe Inst Mol Sci, Bundoora, Vic 3086, Australia

[2] Univ Ghent, Lab Expt Canc Res, Dept Radiat Oncol & Expt Canc Res, Ghent, Belgium

来源：

NUCLEIC ACIDS RESEARCH | 2019年 / 47卷 / D1期

基金：

澳大利亚研究理事会; 英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

MICROVESICLES; EXOSOMES;

D O I：

10.1093/nar/gky1029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Extracellular vesicles (EVs) are membranous vesicles that are released by both prokaryotic and eukaryotic cells into the extracellular microenvironment. EVs can be categorised as exosomes, ectosomes or shedding microvesicles and apoptotic bodies based on the mode of biogenesis. EVs contain biologically active cargo of nucleic acids, proteins, lipids and metabolites that can be altered based on the precise state of the cell. Vesiclepedia (http://www.microvesicles.org) is a web-based compendium of RNA, proteins, lipids and metabolites that are identified in EVs from both published and unpublished studies. Currently, Vesiclepedia contains data obtained from 1254 EV studies, 38 146 RNA entries, 349 988 protein entries and 639 lipid/metabolite entries. Vesiclepedia is publicly available and allows users to query and download EV cargo based on different search criteria. The mode of EV isolation and characterization, the biophysical and molecular properties and EV-METRIC are listed in the database aiding biomedical scientists in assessing the quality of the EV preparation and the corresponding data obtained. In addition, FunRich-based Vesiclepedia plugin is incorporated aiding users in data analysis.

引用

页码：D516 / D519

页数：4

共 16 条

[1] Intercellular transfer of the oncogenic receptor EGFrvIII by microvesicles derived from tumour cells [J].

Al-Nedawi, Khalid ;

Meehan, Brian ;

Micallef, Johann ;

Lhotak, Vladimir ;

May, Linda ;

Guha, Abhijit ;

Rak, Janusz .

NATURE CELL BIOLOGY, 2008, 10 (05) :619-U24

[2] Extending gene ontology in the context of extracellular RNA and vesicle communication [J].

Cheung, Kei-Hoi ;

Keerthikumar, Shivakumar ;

Roncaglia, Paola ;

Subramanian, Sai Lakshmi ;

Roth, Matthew E. ;

Samuel, Monisha ;

Anand, Sushma ;

Gangoda, Lahiru ;

Gould, Stephen ;

Alexander, Roger ;

Galas, David ;

Gerstein, Mark B. ;

Hill, Andrew F. ;

Kitchen, Robert R. ;

Lotvall, Jan ;

Patel, Tushar ;

Procaccini, Dena C. ;

Quesenberry, Peter ;

Rozowsky, Joel ;

Raffai, Robert L. ;

Shypitsyna, Aleksandra ;

Su, Andrew I. ;

Thery, Clotilde ;

Vickers, Kasey ;

Wauben, Marca H. M. ;

Mathivanan, Suresh ;

Milosavljevic, Aleksandar ;

Laurent, Louise C. .

JOURNAL OF BIOMEDICAL SEMANTICS, 2016, 7

[3] Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells [J].

Cossetti, Chiara ;

Iraci, Nunzio ;

Mercer, Tim R. ;

Leonardi, Tommaso ;

Alpi, Emanuele ;

Drago, Denise ;

Alfaro-Cervello, Clara ;

Saini, Harpreet K. ;

Davis, Matthew P. ;

Schaeffer, Julia ;

Vega, Beatriz ;

Stefanini, Matilde ;

Zhao, CongJian ;

Muller, Werner ;

Manuel Garcia-Verdugo, Jose ;

Mathivanan, Suresh ;

Bachi, Angela ;

Enright, Anton J. ;

Mattick, John S. ;

Pluchino, Stefano .

MOLECULAR CELL, 2014, 56 (02) :193-204

[4] Extracellular vesicles including exosomes are mediators of signal transduction: Are they protective or pathogenic? [J].

Gangoda, Lahiru ;

Boukouris, Stephanie ;

Liem, Michael ;

Kalra, Hina ;

Mathivanan, Suresh .

PROTEOMICS, 2015, 15 (2-3) :260-271

[5] Platelet extracellular vesicles as biomarkers for arterial thrombosis [J].

Gasecka, Aleksandra ;

Boing, Anita N. ;

Filipiak, Krzysztof J. ;

Nieuwland, Rienk .

PLATELETS, 2017, 28 (03) :228-234

[6] Focus on Extracellular Vesicles: Introducing the Next Small Big Thing [J].

Kalra, Hina ;

Drummen, Gregor P. C. ;

Mathivanan, Suresh .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2016, 17 (02)

[7] Vesiclepedia: A Compendium for Extracellular Vesicles with Continuous Community Annotation [J].

Kalra, Hina ;

Simpson, Richard J. ;

Ji, Hong ;

Aikawa, Elena ;

Altevogt, Peter ;

Askenase, Philip ;

Bond, Vincent C. ;

Borras, Francesc E. ;

Breakefield, Xandra ;

Budnik, Vivian ;

Buzas, Edit ;

Camussi, Giovanni ;

Clayton, Aled ;

Cocucci, Emanuele ;

Falcon-Perez, Juan M. ;

Gabrielsson, Susanne ;

Gho, Yong Song ;

Gupta, Dwijendra ;

Harsha, H. C. ;

Hendrix, An ;

Hill, Andrew F. ;

Inal, Jameel M. ;

Jenster, Guido ;

Kraemer-Albers, Eva-Maria ;

Lim, Sai Kiang ;

Llorente, Alicia ;

Lotvall, Jan ;

Marcilla, Antonio ;

Mincheva-Nilsson, Lucia ;

Nazarenko, Irina ;

Nieuwland, Rienk ;

Nolte-'t Hoen, Esther N. M. ;

Pandey, Akhilesh ;

Patel, Tushar ;

Piper, Melissa G. ;

Pluchino, Stefano ;

Prasad, T. S. Keshava ;

Rajendran, Lawrence ;

Raposo, Graca ;

Record, Michel ;

Reid, Gavin E. ;

Sanchez-Madrid, Francisco ;

Schiffelers, Raymond M. ;

Siljander, Pia ;

Stensballe, Allan ;

Stoorvogel, Willem ;

Taylor, Douglas ;

Thery, Clotilde ;

Valadi, Hadi ;

van Balkom, Bas W. M. .

PLOS BIOLOGY, 2012, 10 (12)

[8] ExoCarta: A Web-Based Compendium of Exosomal Cargo [J].

Keerthikumar, Shivakumar ;

Chisanga, David ;

Ariyaratne, Dinuka ;

Al Saffar, Haidar ;

Anand, Sushma ;

Zhao, Kening ;

Samuel, Monisha ;

Pathan, Mohashin ;

Jois, Markandeya ;

Chilamkurti, Naveen ;

Gangoda, Lahiru ;

Mathivanan, Suresh .

JOURNAL OF MOLECULAR BIOLOGY, 2016, 428 (04) :688-692

[9]

Liem M., 2017, PROTEOMICS, V17, DOI [10.1002/pmic.201600370, DOI 10.1002/PMIC.201600370]

[10] Entrez Gene: gene-centered information at NCBI [J].

Maglott, Donna ;

Ostell, Jim ;

Pruitt, Kim D. ;

Tatusova, Tatiana .

NUCLEIC ACIDS RESEARCH, 2007, 35 :D26-D31

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