Seed-Assisted Effects on Solution-Mediated Phase Transformation: A Case Study of L-Histidine in Antisolvent Crystallization

被引：11

作者：

Liu, Ya ^{[1
,3
]}

Xu, Shijie ^{[1
,3
]}

Liu, Yumin ^{[1
,3
]}

Chen, Mingyang ^{[1
,3
]}

Chen, Yifu ^{[1
,3
]}

Du, Shichao ^{[1
,3
]}

Wang, Yaping ^{[1
,3
]}

Sun, Panpan ^{[1
,3
]}

Sun, Mengmeng ^{[1
,3
]}

Shi, Peng ^{[1
,3
]}

Gong, Junbo ^{[1
,2
,3
]}

机构：

[1] Tianjin Univ, Sch Chem Engn & Technol, State Key Lab Chem Engn, Tianjin 300072, Peoples R China

[2] Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin Key Lab Modern Drug Delivery & High Effic, Tianjin 300072, Peoples R China

[3] Coinnovat Ctr Chem & Chem Engn Tianjin, Tianjin 300072, Peoples R China

来源：

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH | 2018年 / 57卷 / 02期

基金：

中国国家自然科学基金;

关键词：

INDUCTION TIME MEASUREMENT; L-GLUTAMIC ACID; POLYMORPHIC TRANSFORMATION; CRYSTAL-STRUCTURE; NUCLEATION; GROWTH; FORM; QUANTIFICATION; CARBAMAZEPINE; SPECTROSCOPY;

D O I：

10.1021/acs.iecr.7b04762

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

In this study, the effects of crystal nucleation growth on subsequent solvent-mediated phase transformation experiments of L-histidine (L-his) in antisolvent crystallization were performed at 298.15 K. The unexpected acceleration of the overall transformation rate in antisolvent crystallization with solution-mediated phase transformation was found for a methanol volume fraction of 0.35 < x(2) < 0.60. Interestingly, concomitant polymorphs were obtained for a methanol volume fraction of 0.30 <= x(2) <= 0.65 in antisolvent crystallization, whereas only form B was observed for other volume fractions of methanol, which indicated that the concomitant polymorphic phenomenon was the main reason for the accelerated transformation rate in antisolvent crystallization. Furthermore, seed-assisted experiments and suspended solution-mediated phase transformation experiments were designed to uncover the role of the nucleation of form A accompanying with form B in the subsequent transformation process.

引用

页码：784 / 793

页数：10

共 36 条

[1]

Bernstein J, 1999, ANGEW CHEM INT EDIT, V38, P3440, DOI 10.1002/(SICI)1521-3773(19991203)38:23<3440::AID-ANIE3440>3.0.CO

[2]

2-#

[3]

Brittain H.G., 2009, Polymorphism in Pharmaceutical Solids

[4] Mechanistic Features of Polymorphic Transformations: The Role of Surfaces [J].