Seed-Assisted Effects on Solution-Mediated Phase Transformation: A Case Study of L-Histidine in Antisolvent Crystallization

被引：11
作者：
Liu, Ya [1 ,3 ]
Xu, Shijie [1 ,3 ]
Liu, Yumin [1 ,3 ]
Chen, Mingyang [1 ,3 ]
Chen, Yifu [1 ,3 ]
Du, Shichao [1 ,3 ]
Wang, Yaping [1 ,3 ]
Sun, Panpan [1 ,3 ]
Sun, Mengmeng [1 ,3 ]
Shi, Peng [1 ,3 ]
Gong, Junbo [1 ,2 ,3 ]
机构：
[1] Tianjin Univ, Sch Chem Engn & Technol, State Key Lab Chem Engn, Tianjin 300072, Peoples R China
[2] Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin Key Lab Modern Drug Delivery & High Effic, Tianjin 300072, Peoples R China
[3] Coinnovat Ctr Chem & Chem Engn Tianjin, Tianjin 300072, Peoples R China
来源：
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH | 2018年 / 57卷 / 02期
基金：
中国国家自然科学基金;
关键词：
INDUCTION TIME MEASUREMENT; L-GLUTAMIC ACID; POLYMORPHIC TRANSFORMATION; CRYSTAL-STRUCTURE; NUCLEATION; GROWTH; FORM; QUANTIFICATION; CARBAMAZEPINE; SPECTROSCOPY;
D O I：
10.1021/acs.iecr.7b04762
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
In this study, the effects of crystal nucleation growth on subsequent solvent-mediated phase transformation experiments of L-histidine (L-his) in antisolvent crystallization were performed at 298.15 K. The unexpected acceleration of the overall transformation rate in antisolvent crystallization with solution-mediated phase transformation was found for a methanol volume fraction of 0.35 < x(2) < 0.60. Interestingly, concomitant polymorphs were obtained for a methanol volume fraction of 0.30 <= x(2) <= 0.65 in antisolvent crystallization, whereas only form B was observed for other volume fractions of methanol, which indicated that the concomitant polymorphic phenomenon was the main reason for the accelerated transformation rate in antisolvent crystallization. Furthermore, seed-assisted experiments and suspended solution-mediated phase transformation experiments were designed to uncover the role of the nucleation of form A accompanying with form B in the subsequent transformation process.
引用
收藏
页码：784 / 793
页数：10
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