CMOS Low Current Measurement System for Biomedical Applications

被引：58

作者：

Goldstein, Brian ^{[1
]}

Kim, Dongsoo ^{[1
]}

Xu, Jian ^{[2
]}

Vanderlick, T. Kyle ^{[2
]}

Culurciello, Eugenio ^{[3
]}

机构：

[1] Yale Univ, Dept Elect Engn, New Haven, CT 06520 USA

[2] Yale Univ, Dept Chem Engn, New Haven, CT 06520 USA

[3] Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47907 USA

来源：

IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS | 2012年 / 6卷 / 02期

关键词：

Amperometry; biomedical measurements; capacitive feedback; current measurement; integrator; low current measurement system; low noise circuit; noise analysis; potentiostat; voltage-clamp; VLSI POTENTIOSTAT; MEMBRANES; ARRAY;

D O I：

10.1109/TBCAS.2011.2182512

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We present a micro-chip implementation of a low current measurement system for biomedical applications using capacitive feedback that exhibits 190 fA of RMS noise in a 1 kHz bandwidth. The sampling rate is selectable up to 100 kHz. When measuring the amplifier noise with a 10 G Omega resistor and a 47 pF capacitor at the input, typical of cell membrane capacitance in DNA and patch clamp experiments, the measured RMS noise was 2.44 pA on a 50 pA signal in a 10 kHz bandwidth. Two channels were implemented on 630 x 440 mu m(2) using a 0.5-mu m 3-metal 2-poly CMOS process. Each channel consumes 1.5 mW of power from a 3.3 V supply. We measured the characteristics of an artificial lipid bilayer similar to the ones used in DNA sequencing experiments via nanopores.

引用

页码：111 / 119

页数：9

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