The Rotterdam Scan Study: design and update up to 2012

被引：105

作者：

Ikram, M. Arfan ^{[1
,2
]}

van der Lugt, Aad ^{[2
]}

Niessen, Wiro J. ^{[3
,4
]}

Krestin, Gabriel P. ^{[2
]}

Koudstaal, Peter J. ^{[5
]}

Hofman, Albert ^{[1
]}

Breteler, Monique M. B. ^{[1
,6
]}

Vernooij, Meike W. ^{[1
,2
]}

机构：

[1] Erasmus MC Univ, Med Ctr, Dept Epidemiol, NL-3000 CA Rotterdam, Netherlands

[2] Erasmus MC Univ, Med Ctr, Dept Radiol, NL-3000 CA Rotterdam, Netherlands

[3] Erasmus MC Univ, Med Ctr, Biomed Imaging Grp Rotterdam, NL-3000 CA Rotterdam, Netherlands

[4] Delft Univ Technol, Fac Sci Appl, Delft, Netherlands

[5] Erasmus MC Univ, Med Ctr, Dept Neurol, NL-3000 CA Rotterdam, Netherlands

[6] German Ctr Neurodegenerat Dis, DZNE, Bonn, Germany

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 2011年 / 26卷 / 10期

关键词：

Epidemiology; Population-based; Risk factors; Neuroimaging; Cohort study; Dementia; Stroke; Alzheimer's disease; Microbleeds; White matter lesions; Infarcts; Cerebral blood flow; Diffusion tensor imaging; Genetics; WHITE-MATTER LESIONS; SMALL-VESSEL DISEASE; CEREBRAL-BLOOD-FLOW; MAGNETIC-RESONANCE IMAGES; SILENT BRAIN INFARCTS; GENERAL ELDERLY POPULATION; VIRCHOW-ROBIN SPACES; RISK-FACTORS; COGNITIVE IMPAIRMENT; FOLLOW-UP;

D O I：

10.1007/s10654-011-9624-z

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Neuroimaging plays an important role in etiologic research on neurological diseases in the elderly. The Rotterdam Scan Study was initiated as part of the ongoing Rotterdam Study with the aim to unravel causes of neurological disease by performing neuroimaging in a population-based longitudinal setting. In 1995 and 1999 random subsets of the Rotterdam Study underwent neuroimaging, whereas from 2005 onwards MRI has been implemented into the core protocol of the Rotterdam Study. In this paper, we discuss the background and rationale of the Rotterdam Scan Study. We also describe the imaging protocol and post-processing techniques, and highlight the main findings to date. Finally, we make recommendations for future research, which will also be the main focus of investigation in the Rotterdam Scan Study.

引用

页码：811 / 824

页数：14

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