Rabbit M1 and M2 macrophages can be induced by human recombinant GM-CSF and M-CSF

被引：15

作者：

Yamane, Kazuyoshi ^{[1
,2
]}

Leung, Kai-Poon ^{[1
]}

机构：

[1] US Army Dent & Craniofacial Trauma Res & Tissue R, Inst Surg Res, 3650 Chambers Pass,Bldg 3610, Ft Sam Houston, TX 78234 USA

[2] Osaka Dent Univ, Dept Bacteriol, Hirakata, Osaka, Japan

来源：

FEBS OPEN BIO | 2016年 / 6卷 / 09期

关键词：

M1/M2; macrophages; monocytes; Oryctolagus cuniculus; polarization; rabbit; POLARIZATION; ACTIVATION; INFLAMMATION; EXPRESSION; RESPONSES; MODEL;

D O I：

10.1002/2211-5463.12101

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Macrophages can change their phenotype in response to environmental cues. Polarized macrophages are broadly classified into two groups: classical activated M1 and alternative activated M2. Characterization of human macrophages has been widely studied, but polarized macrophages in rabbits have not been characterized. We characterized rabbit macrophages that were polarized using human recombinant GM-CSF and M-CSF. GM-CSF-treated macrophages had higher mRNA expression of proinflammatory cytokines (M1 phenotype) than did the M-CSF-treated counterpart. By contrast, high levels of TGF-beta and IL-10 expression (M2 phenotype) were found in M-CSF-treated macrophages. The present study may be useful to understand roles of polarized macrophages in rabbit disease models.

引用

页码：945 / 953

页数：9

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