Pathological changes of the myocardium in reworsening of anthracycline-induced cardiomyopathy after explant of a left ventricular assist device

被引：2

作者：

Hiraiwa, Hiroaki ^{[1
]}

Okumura, Takahiro ^{[1
]}

Shimizu, Shinya ^{[1
,2
]}

Arao, Yoshihito ^{[1
]}

Oishi, Hideo ^{[1
]}

Kato, Hiroo ^{[1
]}

Kuwayama, Tasuku ^{[1
]}

Yamaguchi, Shogo ^{[1
]}

Haga, Tomoaki ^{[1
]}

Yokoi, Tsuyoshi ^{[1
]}

Kondo, Toru ^{[1
]}

Sugiura, Yuki ^{[1
]}

Kano, Naoaki ^{[1
]}

Watanabe, Naoki ^{[1
]}

Fukaya, Kenji ^{[1
]}

Furusawa, Kenji ^{[1
]}

Sawamura, Akinori ^{[1
]}

Morimoto, Ryota ^{[1
]}

Fujimoto, Kazuro ^{[3
]}

Mutsuga, Masato ^{[3
]}

Usui, Akihiko ^{[3
]}

Murohara, Toyoaki ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi, Japan

[2] Japanese Red Cross Nagoya Daiichi Hosp, Dept Cardiol, Nagoya, Aichi, Japan

[3] Nagoya Univ, Dept Cardiac Surg, Grad Sch Med, Nagoya, Aichi, Japan

来源：

NAGOYA JOURNAL OF MEDICAL SCIENCE | 2020年 / 82卷 / 01期

关键词：

anthracycline-induced cardiomyopathy; left ventricular assist device; cardiac pathology; reworsening heart failure; HEART-FAILURE; RECOVERY; PATIENT; LVAD;

D O I：

10.18999/nagjms.82.1.129

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We herein report the long-term changes in cardiac function and pathological findings after successful explantation of a left ventricular assist device in a 42-year-old patient with anthracycline-induced cardiomyopathy with reworsening heart failure. Endomyocardial biopsy samples revealed that the cardiomyocyte diameter decreased and collagen volume fraction increased just after left ventricular assist device explantation. The collagen volume fraction decreased after 6 months, despite preserved systolic function. At 5 years after left ventricular assist device explantation, the systolic function markedly decreased and cardiomyocyte diameter increased. Pathological changes of the myocardium may enable the identification of cardiac dysfunction prior to echocardiographic changes in patients with reworsening heart failure after left ventricular assist device explantation.

引用

页码：129 / 134

页数：6

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