The BNT162b2 mRNA Vaccine Elicits Robust Humoral and Cellular Immune Responses in People Living With Human Immunodeficiency Virus (HIV)

被引：121

作者：

Woldemeskel, Bezawit A. ^{[1
]}

Karaba, Andrew H. ^{[1
]}

Garliss, Caroline C. ^{[1
]}

Beck, Evan J. ^{[2
]}

Wang, Kristy H. ^{[1
]}

Laeyendecker, Oliver ^{[2
]}

Cox, Andrea L. ^{[1
]}

Blankson, Joel N. ^{[1
]}

机构：

[1] Johns Hopkins Med, Dept Med, Baltimore, MD USA

[2] NIAID, Div Intramural Res, NIH, Baltimore, MD 20892 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2022年 / 74卷 / 07期

关键词：

COVID; mRNA vaccine; PLWH; SARS-CoV-2; IMMUNOGENICITY; SARS-COV-2;

D O I：

10.1093/cid/ciab648

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Previous studies have shown that certain vaccines induce suboptimal responses in people living with human immunodeficiency virus (HIV, PLWH). However, responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines have not been fully characterized in these patients. Here we show that the BNT162b2 vaccine induces robust immune responses comparable to responses in healthy donors.

引用

页码：1268 / 1270

页数：3

共 10 条

[1] Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 in HIV infection: a single-arm substudy of a phase 2/3 clinical trial [J].

Frater, John ;

Ewer, Katie J. ;

Ogbe, Ane ;

Pace, Mathew ;

Adele, Sandra ;

Adland, Emily ;

Alagaratnam, Jasmini ;

Aley, Parvinder K. ;

Ali, Mohammad ;

Ansari, M. Azim ;

Bara, Anna ;

Bittaye, Mustapha ;

Broadhead, Samantha ;

Brown, Anthony ;

Brown, Helen ;

Cappuccini, Federica ;

Cooney, Enya ;

Dejnirattisai, Wanwisa ;

Dold, Christina ;

Fairhead, Cassandra ;

Fok, Henry ;

Folegatti, Pedro M. ;

Fowler, Jamie ;

Gibbs, Charlotte ;

Goodman, Anna L. ;

Jenkin, Daniel ;

Jones, Mathew ;

Makinson, Rebecca ;

Marchevsky, Natalie G. ;

Mujadidi, Yama F. ;

Nguyen, Hanna ;

Parolini, Lucia ;

Petersen, Claire ;

Plested, Emma ;

Pollock, Katrina M. ;

Ramasamy, Maheshi N. ;

Rhead, Sarah ;

Robinson, Hannah ;

Robinson, Nicola ;

Rongkard, Patpong ;

Ryan, Fiona ;

Serrano, Sonia ;

Tipoe, Timothy ;

Voysey, Merryn ;

Waters, Anele ;

Zacharopoulou, Panagiota ;

Barnes, Eleanor ;

Dunachie, Susanna ;

Goulder, Philip ;

Klenerman, Paul .

LANCET HIV, 2021, 8 (08) :E474-E485

[2]

Levy I., IMMUNOGENICITY SAFET, DOI 10.2139/ssrn.3829650

[3] The Duration, Dynamics, and Determinants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Responses in Individual Healthcare Workers [J].

Lumley, Sheila F. ;

Wei, Jia ;

O'Donnell, Denise ;

Stoesser, Nicole E. ;

Matthews, Philippa C. ;

Howarth, Alison ;

Hatch, Stephanie B. ;

Marsden, Brian D. ;

Cox, Stuart ;

James, Tim ;

Peck, Liam J. ;

Ritter, Thomas G. ;

de Toledo, Zoe ;

Cornall, Richard J. ;

Jones, E. Yvonne ;

Stuart, David, I ;

Screaton, Gavin ;

Ebner, Daniel ;

Hoosdally, Sarah ;

Crook, Derrick W. ;

Conlon, Christopher P. ;

Pouwels, Koen B. ;

Walker, A. Sarah ;

Peto, Tim E. A. ;

Walker, Timothy M. ;

Jeffery, Katie ;

Eyre, David W. .

CLINICAL INFECTIOUS DISEASES, 2021, 73 (03) :E699-E709

[4]

Patel Eshan U, 2021, J Clin Microbiol, V59, DOI [10.1101/2020.08.31.20184788, 10.1128/JCM.02257-20]

[5] Initial observations on age, gender, BMI and hypertension in antibody responses to SARS-CoV-2 BNT162b2 vaccine [J].

Pellini, Raul ;

Venuti, Aldo ;

Pimpinelli, Fulvia ;

Abril, Elva ;

Blandino, Giovanni ;

Campo, Flaminia ;

Conti, Laura ;

De Virgilio, Armando ;

De Marco, Federico ;

Di Domenico, Enea Gino ;

Di Bella, Ornella ;

Di Martino, Simona ;

Ensoli, Fabrizio ;

Giannarelli, Diana ;

Mandoj, Chiara ;

Manciocco, Valentina ;

Marchesi, Paolo ;

Mazzola, Francesco ;

Moretto, Silvia ;

Petruzzi, Gerardo ;

Petrone, Fabrizio ;

Pichi, Barbara ;

Pontone, Martina ;

Zocchi, Jacopo ;

Vidiri, Antonello ;

Vujovic, Branka ;

Piaggio, Giulia ;

Morrone, Aldo ;

Ciliberto, Gennaro .

ECLINICALMEDICINE, 2021, 36

[6] Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine [J].

Polack, Fernando P. ;

Thomas, Stephen J. ;

Kitchin, Nicholas ;

Absalon, Judith ;

Gurtman, Alejandra ;

Lockhart, Stephen ;

Perez, John L. ;

Perez Marc, Gonzalo ;

Moreira, Edson D. ;

Zerbini, Cristiano ;

Bailey, Ruth ;

Swanson, Kena A. ;

Roychoudhury, Satrajit ;

Koury, Kenneth ;

Li, Ping ;

Kalina, Warren V. ;

Cooper, David ;

Frenck, Robert W., Jr. ;

Hammitt, Laura L. ;

Tureci, Ozlem ;

Nell, Haylene ;

Schaefer, Axel ;

Unal, Serhat ;

Tresnan, Dina B. ;

Mather, Susan ;

Dormitzer, Philip R. ;

Sahin, Ugur ;

Jansen, Kathrin U. ;

Gruber, William C. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (27) :2603-2615

[7] Safety and antibody response to the first dose of severe acute respiratory syndrome coronavirus 2 messenger RNA vaccine in persons with HIV [J].

Ruddy, Jake A. ;

Boyarsky, Brian J. ;

Werbel, William A. ;

Bailey, Justin R. ;

Karaba, Andrew H. ;

Garonzik-Wang, Jacqueline M. ;

Segev, Dorry L. ;

Durand, Christine M. .

AIDS, 2021, 35 (11) :1872-1874

[8] COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses [J].

Sahin, Ugur ;

Muik, Alexander ;

Derhovanessian, Evelyna ;

Vogler, Isabel ;

Kranz, Lena M. ;

Vormehr, Mathias ;

Baum, Alina ;

Pascal, Kristen ;

Quandt, Jasmin ;

Maurus, Daniel ;

Brachtendorf, Sebastian ;

Loerks, Verena ;

Sikorski, Julian ;

Hilker, Rolf ;

Becker, Dirk ;

Eller, Ann-Kathrin ;

Gruetzner, Jan ;

Boesler, Carsten ;

Rosenbaum, Corinna ;

Kuehnle, Marie-Cristine ;

Luxemburger, Ulrich ;

Kemmer-Brueck, Alexandra ;

Langer, David ;

Bexon, Martin ;

Bolte, Stefanie ;

Kariko, Katalin ;

Palanche, Tania ;

Fischer, Boris ;

Schultz, Armin ;

Shi, Pei-Yong ;

Fontes-Garfias, Camila ;

Perez, John L. ;

Swanson, Kena A. ;

Loschko, Jakob ;

Scully, Ingrid L. ;

Cutler, Mark ;

Kalina, Warren ;

Kyratsous, Christos A. ;

Cooper, David ;

Dormitzer, Philip R. ;

Jansen, Kathrin U. ;

Tuereci, Oezlem .

NATURE, 2020, 586 (7830) :594-+

[9] Poor immunogenicity of the H1N1 2009 vaccine in well controlled HIV-infected individuals [J].

Tebas, Pablo ;

Frank, Ian ;

Lewis, Mark ;

Quinn, Joseph ;

Zifchak, Larisa ;

Thomas, Aleshia ;

Kenney, Thomas ;

Kappes, Rosemary ;

Wagner, Wayne ;

Maffei, Kathy ;

Sullivan, Kathleen .

AIDS, 2010, 24 (14) :2187-2192

[10] SARS-CoV-2 mRNA vaccines induce broad CD4+ T cell responses that recognize SARS-CoV-2 variants and HCoV-NL63 [J].

Woldemeskel, Bezawit A. ;

Garliss, Caroline C. ;

Blankson, Joel N. .

JOURNAL OF CLINICAL INVESTIGATION, 2021, 131 (10)

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