Obesity and the Use of Antibiotics and Probiotics in Rats

被引：18

作者：

Del Fiol, Fernando de Sa ^{[1
]}

Marciano Tardelli Ferreira, Alessandra Cristina ^{[1
]}

Marciano, Jorge Jose ^{[1
]}

Marques, Maria Claudia ^{[1
]}

Sant'Ana, Luciane Lopes ^{[1
]}

机构：

[1] Univ Sorocaba, Dept Pharmacol, BR-18023000 Sorocaba, SP, Brazil

来源：

CHEMOTHERAPY | 2014年 / 60卷 / 03期

关键词：

Antibiotics; Obesity; Probiotics; TOTAL-BODY WATER; GUT MICROBIOTA; SACCHAROMYCES-BOULARDII; INTESTINAL MICROBIOTA; GROWTH PROMOTERS; MASS INDEX; WEIGHT; LIFE; FAT; PREVENTION;

D O I：

10.1159/000371737

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Obesity has become a major public health challenge in recent years. Recent studies suggest that alterations of the gut microbiota by antibiotics could play an important role in obesity. Methods: We investigated this topic using 60 Wistar rats, which were divided into 3 experimental groups: rats treated with amoxicillin, rats treated with amoxicillin plus Saccharomyces boulardii and controls. Treatments were administered over the course of 2 weeks. Tetrapolar bioelectric impedance analysis and anthropometric evaluations were conducted. Results: The body mass index was significantly lower for the animals in the control group (p = 0.034). The same result was observed for the Lee index: the control group had a lower index than the 2 groups that received antibiotic treatment (p = 0.0019). The total body water data demonstrated that the control group had the greatest amount of body water (279.1 g, p = 0.0243). Conclusions: The groups treated with the antibiotic exhibited a greater accumulation of body fat than the control group. (C) 2015 S. Karger AG, Basel

引用

页码：162 / 167

页数：6

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