Detecting Mycobacterium tuberculosis Infection in Children Migrating to Australia

被引：2

作者：

Laemmle-Ruff, Ingrid ^{[1
,2
]}

Graham, Stephen M. ^{[1
,2
,3
]}

Williams, Bridget ^{[1
]}

Horyniak, Danielle ^{[1
,4
]}

Majumdar, Suman S. ^{[1
,3
,4
,5
]}

Paxton, Georgia A. ^{[2
,3
]}

Caplice, Lila V. Soares ^{[6
]}

Hellard, Margaret E. ^{[1
,3
,4
,5
]}

Trauer, James M. ^{[1
,3
,4
,5
]}

机构：

[1] Burnet Inst, Melbourne, Vic, Australia

[2] Royal Childrens Hosp, Melbourne, Vic, Australia

[3] Univ Melbourne, Melbourne, Vic, Australia

[4] Monash Univ, Melbourne, Vic, Australia

[5] Alfred Hosp, Melbourne, Vic, Australia

[6] Australian Govt, Dept Home Affairs, Canberra, ACT, Australia

来源：

EMERGING INFECTIOUS DISEASES | 2022年 / 28卷 / 09期

基金：

英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

LOW-INCIDENCE COUNTRIES; LATENT TUBERCULOSIS; ACTIVE TUBERCULOSIS; SCREENING-PROGRAMS; COST-EFFECTIVENESS; MIGRANTS; ENTRY; RISK; EPIDEMIOLOGY; MANAGEMENT;

D O I：

10.3201/eid2809.212426

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In 2015, Australia updated premigration screening for tuberculosis (TB) disease in children 2-10 years of age to include testing for infection with Mycobacterium tuberculosis and enable detection of latent TB infection (LTBI). We analyzed TB screening results in children <15 years of age during November 2015-June 2017. We found 45,060 child applicants were tested with interferon-gamma release assay (IGRA) (57.7% of tests) or tuberculin skin test (TST) (42.3% of tests). A total of 21 cases of TB were diagnosed: 4 without IGRA or TST, 10 with positive IGRA or TST, and 7 with negative results. LTBI was detected in 3.3% (1,473/44,709) of children, for 30 applicants screened per LTBI case detected. LTBI-associated factors included increasing age, TB contact, origin from a higher TB prevalence region, and testing by TST. Detection of TB and LTBI benefit children, but the updated screening program's effect on TB in Australia is likely to be limited.

引用

页码：1833 / 1841

页数：9

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