Taxezopidines M and N, taxoids from the Japanese yew, Taxus cuspidata

被引：15

作者：

Morita, H ^{[1
]}

Machida, I ^{[1
]}

Hirasawa, Y ^{[1
]}

Kobayashi, J ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 06期

关键词：

D O I：

10.1021/np0500880

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new taxoids, taxezopidines M (1) and N (2), have been isolated from seeds of the Japanese yew, Taxus cuspidata, and new structures were elucidated on the basis of spectroscopic data. The absolute configuration of a 3-N, N-(dimethylamino)-3-phenylpropanoyl group in 1 and 2 was determined to be R in each case by chiral HPLC analysis. The effect of 1 and 2 on the CaCl2-induced depolymerization of microtubules was investigated.

引用

页码：935 / 937

页数：3

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