Improving Validation Practices in "Omics" Research

被引：169

作者：

Ioannidis, John P. A. ^{[3
,4
,5
]}

Khoury, Muin J. ^{[1
,2
]}

机构：

[1] Ctr Dis Control & Prevent, Off Publ Hlth Genom, Atlanta, GA 30333 USA

[2] NCI, Div Canc Control & Populat Sci, NIH, Rockville, MD 20852 USA

[3] Stanford Univ, Sch Med, Dept Med, Stanford Prevent Res Ctr, Stanford, CA 94305 USA

[4] Stanford Univ, Sch Med, Dept Hlth Res & Policy, Stanford, CA 94305 USA

[5] Stanford Univ, Sch Humanities & Sci, Dept Stat, Stanford, CA 94305 USA

来源：

SCIENCE | 2011年 / 334卷 / 6060期

关键词：

BIOINFORMATICS; PROTEOMICS;

D O I：

10.1126/science.1211811

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

"Omics" research poses acute challenges regarding how to enhance validation practices and eventually the utility of this rich information. Several strategies may be useful, including routine replication, public data and protocol availability, funding incentives, reproducibility rewards or penalties, and targeted repeatability checks.

引用

页码：1230 / 1232

页数：3

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