miR-106a promotes growth and metastasis of non-small cell lung cancer by targeting PTEN

被引：1

作者：

Xie, Xiao ^{[1
]}

Liu, Hong-Tao ^{[2
]}

Mei, Ju ^{[1
]}

Ding, Fang-Bao ^{[1
]}

Xiao, Hai-Bo ^{[1
]}

Hu, Feng-Qing ^{[1
]}

Hu, Rui ^{[1
]}

Wang, Ming-Song ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Xin Hua Hosp, Sch Med, Dept Cardiothorac Surg, Shanghai 200092, Peoples R China

[2] Soochow Univ, Affiliated Hosp 1, Dept Cardiothorac Surg, Suzhou 215006, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2015年 / 8卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Non-small cell lung cancer; miR-106a; PTEN; proliferation; migration; invasion; PROLIFERATION; MICRORNAS; INVASION; PATHWAY;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs are a class of small non-coding RNAs that play essential roles in cancer development and progression. Recent studies suggested that abnormal expression of miRNAs occurs frequently in non-small cell lung cancer (NSCLC) tissues compared to adjacent normal tissues. In this study, we investigated the expression and the biological roles of miR-106a in non-small cell lung cancer. Our results showed that miR-106a was up-regulated in NSCLC tissues and cell lines. Inhibition of miR-106a in NSCLC cells substantially inhibited cell proliferation, migration, and invasion. Phosphatase and tensin homolog (PTEN) was identified as a direct target of miR-106a, and over-expression of miR-106a suppressed PTEN by direct binding to its 3'-untranslated region (3'-UTR). Furthermore, the presence of miR-106a was inversely correlated with PTEN in NSCLC tissues. Overall, this study suggested that miR-106a inhibited the growth and metastasis of NSCLC cells by decreasing PTEN expression. These data provide novel insights with potential therapeutic applications for the treatment of NSCLC.

引用

页码：3827 / 3834

页数：8

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