Correlation between efficacy and structure of recombinant epitope vaccines against bovine type O foot and mouth disease virus

被引：13
|
作者：
Fang, Mingli [1 ]
Li, Jianli [2 ,3 ]
Wang, Hua [1 ]
Yang, Ming [4 ]
Zhang, Yongsheng [1 ]
Zhou, Lei [1 ]
Wei, Hongfei [1 ]
Yang, Guang [1 ]
Yu, Yue
Wei, Xuefeng [5 ]
Yu, Yongli
Wang, Liying [1 ]
Wan, Min [1 ]
机构：
[1] Jilin Univ, Dept Mol Biol, Norman Bethune Coll Med, Changchun 130021, Peoples R China
[2] Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Jiangsu, Peoples R China
[3] Tianjin Ringpu Biotechnol Co Ltd, Natl Certified Enterprise Tech Ctr, Tianjin 300300, Peoples R China
[4] Jilin Univ, Dept Immunol, Norman Bethune Coll Med, Changchun 130021, Peoples R China
[5] Inner Mongolia Jinyu Grp Baoling Biopharmaceut Co, Hohhot 013300, Inner Mongolia, Peoples R China
来源：
BIOTECHNOLOGY LETTERS | 2012年 / 34卷 / 05期
关键词：
Foot and mouth disease virus; Recombinant epitope vaccine; RGD sequence of B cell epitope; VP1 capsid protein; PEPTIDE; CATTLE; VP1; IMMUNOGENICITY; PROTECTION; RESPONSES; PROTEIN; REGION;
D O I：
10.1007/s10529-012-0856-0
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
To develop recombinant epitope vaccines against foot-and-mouth disease virus (FMDV), genes coding for six recombinant proteins (rP1-rP6) consisting of different combinations of B cell and T cell epitope from VP1 capsid protein (VP1) of type O FMDV were constructed and the 3D structure of these proteins analyzed. This revealed a surface-exposed RGD sequence of B cell epitopes in all six recombinant proteins as that in VP1 of FMDV and rP1, rP2 and rP4 globally mimicked the backbone conformation of the VP1. rP1, rP2 and rP4 stimulated guinea pigs to produce higher level of neutralizing antibodies capable of protecting suckling mice against FMDV challenge. rP1 stimulated cattle to produce FMDV-neutralizing antibody. The data suggest that an efficient recombinant epitope vaccine against FMDV should share local similarities with the natural VP1 of FMDV.
引用
收藏
页码：839 / 847
页数：9
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