Cross-Coupling of Amides by N-C Bond Activation

被引：225

作者：

Meng, Guangrong ^{[1
]}

Shi, Shicheng ^{[1
]}

Szostak, Michal ^{[1
]}

机构：

[1] Rutgers State Univ, Dept Chem, 73 Warren St, Newark, NJ 07102 USA

来源：

SYNLETT | 2016年 / 27卷 / 18期

关键词：

amides; cross-coupling; N-C bond activation; Suzuki coupling; decarbonylative coupling; C-H activation; palladium; nickel; CHEMOSELECTIVE KETONE SYNTHESIS; TWISTED AMIDES; NICKEL CATALYSIS; ORGANOMETALLIC REAGENTS; ROTATIONAL PATHWAY; ORGANIC-SYNTHESIS; CLEAVAGE; NITROGEN; METAL; RESONANCE;

D O I：

10.1055/s-0036-1588080

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In recent years, significant conceptual advances have taken place in the field of amide bond cross-coupling. Mild and selective functionalization of amides by transition-metal catalysis has an enormous potential for widespread applications in both industry and academia due to the unparalleled prevalence of amide-containing molecules. However, direct metal insertion into the N-C(O) amide bond is extremely difficult as a consequence of amidic resonance. In this account, we summarize our work on the development of new cross-coupling reactions of amides by N-C bond activation, and briefly discuss other modern developments in this area.

引用

页码：2530 / 2540

页数：11

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