Nicotine depedence and salivary cotinine concentration in daily smokers

被引:11
|
作者
Fu, Marcela [3 ]
Martinez-Sanchez, Jose M. [3 ]
Agudo, Antoni [2 ]
Pascual, Jose A. [4 ]
Ariza, Carles [5 ,6 ]
Moncada, Albert [7 ]
Fernandez, Esteve [1 ,3 ]
机构
[1] Hosp Llobregat, Tobacco Control Unit, Canc Control & Prevent Programme, Inst Catala Oncol ICO, Barcelona 199203, Spain
[2] Inst Invest Biomed Bellvitge IDIBELL, Nutr Environm & Canc Grp, Barcelona, Spain
[3] Univ Barcelona, Dept Clin Sci, Hosp Llobregat, E-08007 Barcelona, Spain
[4] Univ Pompeu Fabra, Dept Expt & Hlth Sci, Barcelona, Spain
[5] Agencia Salut Publ Barcelona ASPB, Evaluat & Intervent Methods Unit, Barcelona, Spain
[6] CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain
[7] Terrassa City Council, Hlth Promot Unit, Terrassa, Spain
关键词
cotinine; cross-sectional study; dependence; epidemiology; smoking; FAGERSTROM TEST; GENDER-DIFFERENCES; NATIONAL-HEALTH; DEPENDENCE; SMOKING; CIGARETTE; POPULATION; BIOMARKERS; BARCELONA; PLASMA;
D O I
10.1097/CEJ.0b013e32834a7e59
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
There is scant information on nicotine dependence in smokers not seeking cessation treatment. This study analyses the relationship between nicotine dependence, measured by the Fagerstrom Test for Nicotine Dependence (FTND), and salivary cotinine concentration in a sample of smokers from the general population. We conducted a cross-sectional study (2004-2005) of a representative sample of the general population of Barcelona, Spain (n = 1245). The analysis included 196 daily smokers aged more than 16 years. Information on smoking was obtained by questionnaire and cotinine concentration was determined in saliva. Geometric means of cotinine concentration by every single FTND item were computed, and multivariate linear regression was used to explore the relationship among these variables. Participants smoked a mean of 17.0 cigarettes per day, and the mean FTND score was 3.27 (95% confidence interval: 2.92-3.61). Around 17% of subjects (95% confidence interval: 12.0-22.5%) had high nicotine dependence. Cotinine concentration differed significantly by nicotine dependence levels. In a multiple linear regression model including the sum of the FTND items 2, 3, and 6, and the single FTND items 1, 4, and 5, adjusted for sex, the time to first cigarette after waking up (item 1), the number of cigarettes smoked daily (item 4), and smoking more in the first hours of the day (item 5) were significantly related to salivary cotinine concentration (R-2 = 0.414). Salivary cotinine levels were associated with nicotine dependence as measured by the FTND, especially with the items on daily tobacco consumption, time to first cigarette after waking up, and smoking more in the first hours of the day. European Journal of Cancer Prevention 21:96-102 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
引用
收藏
页码:96 / 102
页数:7
相关论文
共 50 条
  • [41] MEASUREMENT OF URINE NICOTINE AND COTININE LEVELS OF PASSIVE SMOKERS USING HPLC
    HARIHARAN, M
    VANNOORD, T
    CLINICAL CHEMISTRY, 1990, 36 (06) : 1026 - 1026
  • [42] Environmental tobacco smoke: Nicotine and cotinine concentration in semen
    Istituto Superior di Senità, V. le Regina Elena 299, 00161 Rome, Italy
    不详
    ENVIRON. RES., 1 (69-72):
  • [43] Cotinine (a metabolite of nicotine) suppresses the growth of hematopoietic progenitor cells at the concentration range equivalent to its serum levels in smokers
    Takahashi, M
    Shigeno, N
    Narita, M
    Takahashi, H
    Furukawa, T
    Koike, T
    Aizawa, Y
    STEM CELLS, 1999, 17 (02) : 125 - 126
  • [44] Assessment of salivary cotinine concentration among general non-smokers population: Before and after Spanish smoking legislations
    Lidon-Moyano, Cristina
    Fu, Marcela
    Perez-Ortuno, Raul
    Ballbe, Montse
    Sampedro-Vida, Marc
    Carlos Martin-Sanchez, Juan
    Pascual, Jose A.
    Fernandez, Esteve
    Martinez-Sanchez, Jose M.
    CANCER EPIDEMIOLOGY, 2017, 51 : 87 - 91
  • [45] A simultaneous measurement of nicotine and cotinine in the urine of smokers and passive smokers by high-performance liquid chromatography
    Glowacki, R
    Brozik, H
    Sabanty, W
    Bald, E
    CHEMIA ANALITYCZNA, 2000, 45 (02): : 205 - 214
  • [46] EFFECT OF NICOTINE AND COTININE ON THE PRODUCTION OF OXYGEN FREE-RADICALS BY NEUTROPHILS IN SMOKERS AND NON-SMOKERS
    SRIVASTAVA, ED
    HALLETT, MB
    RHODES, J
    HUMAN TOXICOLOGY, 1989, 8 (06): : 461 - 463
  • [47] CORRELATIONS BETWEEN URINARY NICOTINE OR COTININE AND URINARY MUTAGENICITY IN SMOKERS ON CONTROLLED DIETS
    RAHN, CA
    HOWARD, G
    RICCIO, E
    DOOLITTLE, DJ
    ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 1991, 17 (04) : 244 - 252
  • [48] Increased nicotine and cotinine levels in smokers with schizophrenia and schizoaffective disorder is not a metabolic effect
    Williams, JM
    Ziedonis, DM
    Abanyie, F
    Steinberg, ML
    Foulds, J
    Benowitz, NL
    SCHIZOPHRENIA RESEARCH, 2005, 79 (2-3) : 323 - 335
  • [49] EVALUATION OF URINARY BTEX, NICOTINE, AND COTININE AS BIOMARKERS OF AIRBORNE POLLUTANTS IN NONSMOKERS AND SMOKERS
    Brajenovic, Natasa
    Karaconji, Irena Brcic
    Bulog, Aleksandar
    JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 2015, 78 (17): : 1133 - 1136
  • [50] NICOTINE INTAKE IN YOUNG SMOKERS - LONGITUDINAL-STUDY OF SALIVA COTININE CONCENTRATIONS
    MCNEILL, AD
    JARVIS, MJ
    STAPLETON, JA
    WEST, RJ
    BRYANT, A
    AMERICAN JOURNAL OF PUBLIC HEALTH, 1989, 79 (02) : 172 - 175