Neurochemical and Behavioural Changes in Rat Models of Depression

被引：7

作者：

Skelin, Ivan ^{[1
]}

Kovacevic, Tomislav ^{[1
,2
]}

Diksic, Mirko ^{[1
,2
]}

机构：

[1] McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Cone Neurosurg Res Lab, Montreal, PQ H3A 2B4, Canada

[2] Univ Osijek, Fac Med, Osijek 31000, Croatia

来源：

CROATICA CHEMICA ACTA | 2011年 / 84卷 / 02期

关键词：

depression; olfactory bulbectomized rat model of depression; Flinders sensitive line rat; Flinders Resistant line rat; animal model of depression; FLINDERS-SENSITIVE-LINE; OLFACTORY BULBECTOMIZED RATS; CHRONIC ANTIDEPRESSANT TREATMENT; REGIONAL SEROTONIN SYNTHESIS; CEREBRAL GLUCOSE-UTILIZATION; IN-VIVO MICRODIALYSIS; GENETIC ANIMAL-MODEL; BRAIN 5-HT SYNTHESIS; RECEPTOR ANTAGONIST; NUCLEUS-ACCUMBENS;

D O I：

10.5562/cca1817

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Depression is one of the most prevalent psychiatric disorders with significant lifetime prevalence. The study of human depression is hindered by the relatively significant heterogeneity of this disorder. As a result of these heterogeneities, studies using a sound and representative animal model of depression are extremely valuable and, in general, provide important information regarding the neurochemical/biological changes occurring during depression and the subsequent treatment of its symptoms. In this review we concentrate on two solid rat models of depression: olfactory bulbectomized (OBX) rats and Flinders Sensitive Line (FSL) of rats. These two models were selected because they possess all three characteristics of a good animal model; face, predictive and constructive validities. We also emphasize the brain serotonergic system and we discuss the open field and forced swim test to assess behaviour. (doi: 10.5562/cca1817)

引用

页码：287 / 299

页数：13

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