A Subset of Cancer-Associated Fibroblasts Determines Therapy Resistance

被引：70

作者：

Huelsken, Joerg ^{[1
]}

Hanahan, Douglas ^{[2
]}

机构：

[1] Swiss Fed Inst Technol Lausanne EPFL, ISREC Swiss Inst Expt Canc Res, Sch Life Sci, Lab Tumor Heterogene & Stemness Canc, CH-1015 Lausanne, Switzerland

[2] Swiss Fed Inst Technol Lausanne EPFL, ISREC Swiss Inst Expt Canc Res, Sch Life Sci, Lab Translat Oncol, CH-1015 Lausanne, Switzerland

来源：

CELL | 2018年 / 172卷 / 04期

关键词：

PANCREATIC-CANCER;

D O I：

10.1016/j.cell.2018.01.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

While functional heterogeneity of fibroblastic cells populating the tumor microenvironment is increasingly recognized, lack of definitive markers complicates elucidation of roles among ostensibly distinctive fibroblastic states. In this issue of Cell, Su et al. characterize a new pro-tumorigenic cancer-associated fibroblast subset mediating chemoresistance defined and driven by a novel signaling pathway.

引用

页码：643 / 644

页数：2

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