Invariant natural killer T cells direct B cell responses to cognate lipid antigen in an IL-21-dependent manner

被引：171

作者：

King, Irah L. ^{[1
]}

Fortier, Anne ^{[1
]}

Tighe, Michael ^{[1
]}

Dibble, John ^{[1
]}

Watts, Gerald F. M. ^{[2
]}

Veerapen, Natacha ^{[3
]}

Haberman, Ann M. ^{[4
]}

Besra, Gurdyal S. ^{[3
]}

Mohrs, Markus ^{[1
]}

Brenner, Michael B. ^{[2
]}

Leadbetter, Elizabeth A. ^{[1
]}

机构：

[1] Trudeau Inst Inc, Saranac Lake, NY 12983 USA

[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Rheumatol, Boston, MA 02115 USA

[3] Univ Birmingham, Sch Biosci, Birmingham, W Midlands, England

[4] Yale Univ, Sch Med, Dept Lab Med, New Haven, CT 06510 USA

来源：

NATURE IMMUNOLOGY | 2012年 / 13卷 / 01期

基金：

英国惠康基金; 美国国家卫生研究院; 英国医学研究理事会;

关键词：

CXC CHEMOKINE RECEPTOR-5; MARGINAL ZONE; NKT CELLS; ANTIBODY-RESPONSES; CUTTING EDGE; IN-VIVO; IMMUNOGLOBULIN; IL-21; DIFFERENTIATION; ACTIVATION;

D O I：

10.1038/ni.2172

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mouse invariant natural killer T cells (iNKT cells) provide cognate and noncognate help for lipid and protein-specific B cells, respectively. However, the long-term outcome for B cells after cognate help is provided by iNKT cells is unknown at present. Here we found that cognate iNKT cell help resulted in a B cell differentiation program characterized by extrafollicular plasmablasts, germinal-center formation, affinity maturation and a robust primary immunoglobulin G (IgG) antibody response that was uniquely dependent on iNKT cell-derived interleukin 21 (IL-21). However, cognate help from iNKT cells did not generate an enhanced humoral memory response. Thus, cognate iNKT cell help for lipid-specific B cells induces a unique signature that is a hybrid of classic T cell-dependent and T cell-independent type 2 B cell responses.

引用

页码：44 / U64

页数：8

共 44 条

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